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MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis

MicroRNAs have been confirmed to function as diagnostic biomarkers for esophageal cancer (EC). This study aimed to investigate the diagnostic potential of miR-375 in the plasma or extracellular vesicles (EVs) of esophageal cancers (ECs). METHODS: miRNAs with diagnostic potential were identified thro...

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Autores principales: Chen, Jie, Cai, Zhigang, Hu, Jing, Zhou, Lixia, Zhang, Peili, Xu, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901947/
https://www.ncbi.nlm.nih.gov/pubmed/36749234
http://dx.doi.org/10.1097/MD.0000000000032826
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author Chen, Jie
Cai, Zhigang
Hu, Jing
Zhou, Lixia
Zhang, Peili
Xu, Xiaoping
author_facet Chen, Jie
Cai, Zhigang
Hu, Jing
Zhou, Lixia
Zhang, Peili
Xu, Xiaoping
author_sort Chen, Jie
collection PubMed
description MicroRNAs have been confirmed to function as diagnostic biomarkers for esophageal cancer (EC). This study aimed to investigate the diagnostic potential of miR-375 in the plasma or extracellular vesicles (EVs) of esophageal cancers (ECs). METHODS: miRNAs with diagnostic potential were identified through public database searches and validated through clinical sample testing. The diagnostic value of miR-375 in plasma and EVs was evaluated via receiver operating characteristic analysis and area under the curve. In addition, expression and survival analyses of the top ten target genes of miR-375 were conducted using the cancer genome atlas database. RESULTS: MiR-375 was identified as a potential biomarker for ECs by searching the gene expression omnibus database. Results of clinical sample measurements showed that miR-375 in plasma or EVs was significantly different between ECs and controls (P < .01), but did not differ by gender or age. receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma. The expression and survival analysis of the top ten target genes for miR-375 showed that only EIF4G3 was significantly associated with survival (P < .05). CONCLUSION: This research shows that miR-375, particularly in EVs, could serve as a biomarker for the diagnosis of ECs.
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spelling pubmed-99019472023-02-08 MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis Chen, Jie Cai, Zhigang Hu, Jing Zhou, Lixia Zhang, Peili Xu, Xiaoping Medicine (Baltimore) 3700 MicroRNAs have been confirmed to function as diagnostic biomarkers for esophageal cancer (EC). This study aimed to investigate the diagnostic potential of miR-375 in the plasma or extracellular vesicles (EVs) of esophageal cancers (ECs). METHODS: miRNAs with diagnostic potential were identified through public database searches and validated through clinical sample testing. The diagnostic value of miR-375 in plasma and EVs was evaluated via receiver operating characteristic analysis and area under the curve. In addition, expression and survival analyses of the top ten target genes of miR-375 were conducted using the cancer genome atlas database. RESULTS: MiR-375 was identified as a potential biomarker for ECs by searching the gene expression omnibus database. Results of clinical sample measurements showed that miR-375 in plasma or EVs was significantly different between ECs and controls (P < .01), but did not differ by gender or age. receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma. The expression and survival analysis of the top ten target genes for miR-375 showed that only EIF4G3 was significantly associated with survival (P < .05). CONCLUSION: This research shows that miR-375, particularly in EVs, could serve as a biomarker for the diagnosis of ECs. Lippincott Williams & Wilkins 2023-02-03 /pmc/articles/PMC9901947/ /pubmed/36749234 http://dx.doi.org/10.1097/MD.0000000000032826 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 3700
Chen, Jie
Cai, Zhigang
Hu, Jing
Zhou, Lixia
Zhang, Peili
Xu, Xiaoping
MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title_full MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title_fullStr MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title_full_unstemmed MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title_short MicroRNA-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
title_sort microrna-375 in extracellular vesicles – novel marker for esophageal cancer diagnosis
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901947/
https://www.ncbi.nlm.nih.gov/pubmed/36749234
http://dx.doi.org/10.1097/MD.0000000000032826
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