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Bioinformatics identify the role of chordin-like 1 in thyroid cancer

The abnormal expression of chordin-like 1 (CHRDL1) is identified in many cancers, while the effect of CHRDL1 in thyroid cancer (THCA) remains unclear. The University of California Santa Cruz, Gene Expression Profiling Interactive Analysis, University of Alabama at Birmingham Cancer, and Gene Express...

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Autores principales: Yu, Jia-Wei, Pang, Rui, Liu, Bo, Zhang, Liang, Zhang, Jie-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901988/
https://www.ncbi.nlm.nih.gov/pubmed/36749222
http://dx.doi.org/10.1097/MD.0000000000032778
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author Yu, Jia-Wei
Pang, Rui
Liu, Bo
Zhang, Liang
Zhang, Jie-Wu
author_facet Yu, Jia-Wei
Pang, Rui
Liu, Bo
Zhang, Liang
Zhang, Jie-Wu
author_sort Yu, Jia-Wei
collection PubMed
description The abnormal expression of chordin-like 1 (CHRDL1) is identified in many cancers, while the effect of CHRDL1 in thyroid cancer (THCA) remains unclear. The University of California Santa Cruz, Gene Expression Profiling Interactive Analysis, University of Alabama at Birmingham Cancer, and Gene Expression Omnibus database (GSE33570, GSE33630, and GSE60542) were used for determining the mRNA and methylation expression of CHRDL1 in tumor and normal tissues. Human Protein Atlas was used for exploring the protein expression level of CHRDL1. The genes correlated to CHRDL1 were assessed by cBioPortal database. The prognostic value of CHRDL1 was evaluated through Kaplan–Meier method, cox regression, and nomogram analysis. Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and gene set enrichment analysis were used for predicting potential function of CHRDL1. The relationship between CHRDL1 and immune cell infiltration was determined by Pearson method. The downregulated mRNA and protein expressions of CHRDL1 were identified in THCA through the analysis of data from The Cancer Genome Atlas, Gene Expression Omnibus, and Human Protein Atlas database. The survival analysis showed that the CHRDL1 expression significantly affected disease-free interval (DFI) and progression-free interval, and CHRDL1 was an independent predictor of DFI. Besides, we found that C-C motif chemokine ligand 21 could significantly affect DFI time when it was co-expressed with CHRDL1. Additionally, the function of CHRDL1 was enriched in cell migration, apoptosis, and immune cell receptor. The downregulated expression of CHRDL1 was observed in THCA and caused poor prognosis. CHRDL1 may be involved in signal pathway related to cancer development and immune response, which suggested it could be a potential biomarker.
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spelling pubmed-99019882023-02-08 Bioinformatics identify the role of chordin-like 1 in thyroid cancer Yu, Jia-Wei Pang, Rui Liu, Bo Zhang, Liang Zhang, Jie-Wu Medicine (Baltimore) 5700 The abnormal expression of chordin-like 1 (CHRDL1) is identified in many cancers, while the effect of CHRDL1 in thyroid cancer (THCA) remains unclear. The University of California Santa Cruz, Gene Expression Profiling Interactive Analysis, University of Alabama at Birmingham Cancer, and Gene Expression Omnibus database (GSE33570, GSE33630, and GSE60542) were used for determining the mRNA and methylation expression of CHRDL1 in tumor and normal tissues. Human Protein Atlas was used for exploring the protein expression level of CHRDL1. The genes correlated to CHRDL1 were assessed by cBioPortal database. The prognostic value of CHRDL1 was evaluated through Kaplan–Meier method, cox regression, and nomogram analysis. Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and gene set enrichment analysis were used for predicting potential function of CHRDL1. The relationship between CHRDL1 and immune cell infiltration was determined by Pearson method. The downregulated mRNA and protein expressions of CHRDL1 were identified in THCA through the analysis of data from The Cancer Genome Atlas, Gene Expression Omnibus, and Human Protein Atlas database. The survival analysis showed that the CHRDL1 expression significantly affected disease-free interval (DFI) and progression-free interval, and CHRDL1 was an independent predictor of DFI. Besides, we found that C-C motif chemokine ligand 21 could significantly affect DFI time when it was co-expressed with CHRDL1. Additionally, the function of CHRDL1 was enriched in cell migration, apoptosis, and immune cell receptor. The downregulated expression of CHRDL1 was observed in THCA and caused poor prognosis. CHRDL1 may be involved in signal pathway related to cancer development and immune response, which suggested it could be a potential biomarker. Lippincott Williams & Wilkins 2023-02-03 /pmc/articles/PMC9901988/ /pubmed/36749222 http://dx.doi.org/10.1097/MD.0000000000032778 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Yu, Jia-Wei
Pang, Rui
Liu, Bo
Zhang, Liang
Zhang, Jie-Wu
Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title_full Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title_fullStr Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title_full_unstemmed Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title_short Bioinformatics identify the role of chordin-like 1 in thyroid cancer
title_sort bioinformatics identify the role of chordin-like 1 in thyroid cancer
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901988/
https://www.ncbi.nlm.nih.gov/pubmed/36749222
http://dx.doi.org/10.1097/MD.0000000000032778
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