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Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease

Amyloidosis is a mainly systemic rare disease and its localized presentation is even less frequent. Systemic forms are often associated with other conditions or entities (such as neoplasms), and a correct etiological study of patients with this disease is essential. A localized presentation has a be...

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Detalles Bibliográficos
Autores principales: Gomes, Sara, Santos, Sara, Silva, Monica, Ferreira, Joana, Ponte, Teresinha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902069/
https://www.ncbi.nlm.nih.gov/pubmed/36756007
http://dx.doi.org/10.7759/cureus.33480
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author Gomes, Sara
Santos, Sara
Silva, Monica
Ferreira, Joana
Ponte, Teresinha
author_facet Gomes, Sara
Santos, Sara
Silva, Monica
Ferreira, Joana
Ponte, Teresinha
author_sort Gomes, Sara
collection PubMed
description Amyloidosis is a mainly systemic rare disease and its localized presentation is even less frequent. Systemic forms are often associated with other conditions or entities (such as neoplasms), and a correct etiological study of patients with this disease is essential. A localized presentation has a better prognosis compared to systemic forms, which underlines the importance of a correct diagnosis. Primary localized amyloidosis in the head and neck region is a rare entity. Primary amyloidosis localized to the sinonasal tract is extremely rare. Although uncommon, case reports have been increasing in the face of new endoscopic and imaging techniques, and the report of these cases is crucial for a better characterization of this entity. Symptoms may include epistaxis, nasal obstruction, facial deformity, and vision changes. A 72-year-old female with a history of frequent nasal congestion with two years’ duration showed no improvement following symptom management. She was referred for nasal endoscopy and biopsy, thereby confirming the diagnosis of amyloidosis. Further diagnostic testing did not show evidence of systemic disease. This case report was previously presented as a poster presentation at the 19th European Congress of Internal Medicine in March 2021.
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spelling pubmed-99020692023-02-07 Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease Gomes, Sara Santos, Sara Silva, Monica Ferreira, Joana Ponte, Teresinha Cureus Internal Medicine Amyloidosis is a mainly systemic rare disease and its localized presentation is even less frequent. Systemic forms are often associated with other conditions or entities (such as neoplasms), and a correct etiological study of patients with this disease is essential. A localized presentation has a better prognosis compared to systemic forms, which underlines the importance of a correct diagnosis. Primary localized amyloidosis in the head and neck region is a rare entity. Primary amyloidosis localized to the sinonasal tract is extremely rare. Although uncommon, case reports have been increasing in the face of new endoscopic and imaging techniques, and the report of these cases is crucial for a better characterization of this entity. Symptoms may include epistaxis, nasal obstruction, facial deformity, and vision changes. A 72-year-old female with a history of frequent nasal congestion with two years’ duration showed no improvement following symptom management. She was referred for nasal endoscopy and biopsy, thereby confirming the diagnosis of amyloidosis. Further diagnostic testing did not show evidence of systemic disease. This case report was previously presented as a poster presentation at the 19th European Congress of Internal Medicine in March 2021. Cureus 2023-01-07 /pmc/articles/PMC9902069/ /pubmed/36756007 http://dx.doi.org/10.7759/cureus.33480 Text en Copyright © 2023, Gomes et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Gomes, Sara
Santos, Sara
Silva, Monica
Ferreira, Joana
Ponte, Teresinha
Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title_full Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title_fullStr Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title_full_unstemmed Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title_short Amyloidosis Localized to the Sinonasal Tract: From the Diagnosis to Management of Disease
title_sort amyloidosis localized to the sinonasal tract: from the diagnosis to management of disease
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902069/
https://www.ncbi.nlm.nih.gov/pubmed/36756007
http://dx.doi.org/10.7759/cureus.33480
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