Cargando…

Downregulation of CAMK2N1 due to DNA Hypermethylation Mediated by DNMT1 that Promotes the Progression of Prostate Cancer

Calcium/calmodulin-dependentprotein kinase II inhibitor I (CAMK2N1) as one of the tumor suppressor genes is significantly downregulated in prostate cancer (PCa). Reduced expression of CAMK2N1 is positively correlated with PCa progression. However, the mechanisms of CAMK2N1 downregulation in PCa are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peng, Wei, Feng, Huan, Pang, Linhao, Zhang, Junfeng, Hao, Yi, Wei, Xian, Xia, Qidong, Wei, Zhewen, Song, Wen, Wang, Shaogang, Liu, Jihong, Chen, Ke, Wang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902116/ https://www.ncbi.nlm.nih.gov/pubmed/36755811 http://dx.doi.org/10.1155/2023/4539045

Ejemplares similares

DNMT1-maintained hypermethylation of Krüppel-like factor 5 involves in the progression of clear cell renal cell carcinoma
por: Fu, Rong-Jie, et al.
Publicado: (2017)

Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion
por: Wu, Rile, et al.
Publicado: (2019)

LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1
por: Yu, Xiao, et al.
Publicado: (2021)

Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas
por: Gömöri, Éva, et al.
Publicado: (2012)

The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer
por: Wang, Tao, et al.
Publicado: (2014)

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
por: Kerdivel, Gwenneg, et al.
Publicado: (2023)

CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling
por: Wang, Tao, et al.
Publicado: (2014)

DNMT 1 maintains hypermethylation of CAG promoter specific region and prevents expression of exogenous gene in fat-1 transgenic sheep
por: Yang, Chunrong, et al.
Publicado: (2017)

Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1
por: Zhang, Yue, et al.
Publicado: (2018)

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis
por: Yuan, Ziqiang, et al.
Publicado: (2016)

SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation
por: Acun, Tolga, et al.
Publicado: (2011)

Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
por: Wiseman, Ashley K., et al.
Publicado: (2022)

CAMKs support development of acute myeloid leukemia
por: Kang, Xunlei, et al.
Publicado: (2018)

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features
por: Xing, Xiangling, et al.
Publicado: (2022)

Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer
por: Cheng, Y Y, et al.
Publicado: (2008)

Hypermethylation Leads to Bone Morphogenetic Protein 6 Downregulation in Hepatocellular Carcinoma
por: He, Yinghua, et al.
Publicado: (2014)

FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
por: Lin, Zhuoying, et al.
Publicado: (2021)

Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer
por: Lei, Yangyang, et al.
Publicado: (2020)

ZIC1 Is Downregulated through Promoter Hypermethylation, and Functions as a Tumor Suppressor Gene in Colorectal Cancer
por: Gan, Lihong, et al.
Publicado: (2011)

The role of aberrant promoter hypermethylation of DACT1 in bladder urothelial carcinoma
por: Cheng, Huan, et al.
Publicado: (2012)

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders
por: Akita, Tenpei, et al.
Publicado: (2018)

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice
por: Sasaki, Keisuke, et al.
Publicado: (2019)

Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa
por: Takano, Hikaru, et al.
Publicado: (2020)

OR09-2 The RCAN 1.4 Metastasis Progression Suppressor Gene is Hypermethylated at Intron 1 and Downregulated in Papillary Thyroid Cancer
por: Li, Wei, et al.
Publicado: (2022)

Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A
por: Guo, Guangyu, et al.
Publicado: (2023)

Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer
por: Chen, Mingquan, et al.
Publicado: (2011)

AB225. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer
por: Wang, T, et al.
Publicado: (2014)

Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression
por: Wang, Jianhua, et al.
Publicado: (2021)

Downregulation of SM22α protein by hypermethylation of its promoter in colorectal cancer
por: Liu, Yabin, et al.
Publicado: (2018)

Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas
por: Ma, Hou-Shi, et al.
Publicado: (2018)

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer
por: He, ShanShan, et al.
Publicado: (2011)

The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1
por: Li, Zhuo, et al.
Publicado: (2021)

CAMK2γ Antagonizes mTORC1 Activation during Hepatocarcinogenesis
por: Meng, Zhipeng, et al.
Publicado: (2016)

Downregulation of microRNA-132 by DNA hypermethylation is associated with cell invasion in colorectal cancer
por: Qin, Jun, et al.
Publicado: (2015)

Prognostic and Immunological Value of Angiotensin-Converting Enzyme 2 in Pan-Cancer
por: Feng, Huan, et al.
Publicado: (2020)

Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development
por: Zhang, Bao-gui, et al.
Publicado: (2016)

Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2
por: Huh, Sung Un, et al.
Publicado: (2015)

The Effect of Beta-Boswellic Acid on the Expression of Camk4 and Camk2α Genes in the PC12 Cell Line
por: Jebelli, Asiyeh, et al.
Publicado: (2020)

Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice
por: Rigter, Pomme M.F., et al.
Publicado: (2022)

Fibulin-1 Is Downregulated Through Promoter Hypermethylation in Colorectal Cancer: A Consort Study
por: Xu, Zhiying, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_v9525q7k3qmgugacbg0a6uq6g4