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Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1

Thirdhand smoke (THS) refers to residual tobacco smoking pollutants that can be adsorbed to indoor surfaces and dust and persist for years after active smoking. THS-related chemicals such as N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific lung...

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Autores principales: Peng, Jiamin, Shuopeng, Jia, Wang, Huiju, Wang, Xin, Wang, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902119/
https://www.ncbi.nlm.nih.gov/pubmed/36756386
http://dx.doi.org/10.1155/2023/3407313
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author Peng, Jiamin
Shuopeng, Jia
Wang, Huiju
Wang, Xin
Wang, Ligang
author_facet Peng, Jiamin
Shuopeng, Jia
Wang, Huiju
Wang, Xin
Wang, Ligang
author_sort Peng, Jiamin
collection PubMed
description Thirdhand smoke (THS) refers to residual tobacco smoking pollutants that can be adsorbed to indoor surfaces and dust and persist for years after active smoking. THS-related chemicals such as N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific lung carcinogens that involved in lung cancer development and progression. In this study, we computed the differentially expressed genes (DEGs) between THS and paired control samples. THS-related overexpressed genes (OEs) were overlapped with OEs of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Survival analyses of these overlapped genes were performed using LUAD and LUSC data. 6 genes were selected for validation based on their expression levels and prognostic value. Hematological and neurological expressed 1 (HN1) was further selected due to its novelty in LUAD research. The potential roles of HN1 in LUAD were explored in several ways. In summary, HN1 is overexpressed in THS samples and is associated with the prognosis of patients with LUAD. It may promote cancer progression through several pathways and could serve as a potential therapeutic target especially for THS-related LUAD. In-depth mechanistic studies and clinical trials are warranted.
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spelling pubmed-99021192023-02-07 Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1 Peng, Jiamin Shuopeng, Jia Wang, Huiju Wang, Xin Wang, Ligang Comput Math Methods Med Research Article Thirdhand smoke (THS) refers to residual tobacco smoking pollutants that can be adsorbed to indoor surfaces and dust and persist for years after active smoking. THS-related chemicals such as N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific lung carcinogens that involved in lung cancer development and progression. In this study, we computed the differentially expressed genes (DEGs) between THS and paired control samples. THS-related overexpressed genes (OEs) were overlapped with OEs of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Survival analyses of these overlapped genes were performed using LUAD and LUSC data. 6 genes were selected for validation based on their expression levels and prognostic value. Hematological and neurological expressed 1 (HN1) was further selected due to its novelty in LUAD research. The potential roles of HN1 in LUAD were explored in several ways. In summary, HN1 is overexpressed in THS samples and is associated with the prognosis of patients with LUAD. It may promote cancer progression through several pathways and could serve as a potential therapeutic target especially for THS-related LUAD. In-depth mechanistic studies and clinical trials are warranted. Hindawi 2023-01-30 /pmc/articles/PMC9902119/ /pubmed/36756386 http://dx.doi.org/10.1155/2023/3407313 Text en Copyright © 2023 Jiamin Peng et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Peng, Jiamin
Shuopeng, Jia
Wang, Huiju
Wang, Xin
Wang, Ligang
Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title_full Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title_fullStr Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title_full_unstemmed Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title_short Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1
title_sort thirdhand smoke may promote lung adenocarcinoma development through hn1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902119/
https://www.ncbi.nlm.nih.gov/pubmed/36756386
http://dx.doi.org/10.1155/2023/3407313
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