A review of harmonization strategies for quantitative PET

PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and phys...

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Autores principales: Akamatsu, Go, Tsutsui, Yuji, Daisaki, Hiromitsu, Mitsumoto, Katsuhiko, Baba, Shingo, Sasaki, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Invited Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902332/
https://www.ncbi.nlm.nih.gov/pubmed/36607466
http://dx.doi.org/10.1007/s12149-022-01820-x
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author Akamatsu, Go
Tsutsui, Yuji
Daisaki, Hiromitsu
Mitsumoto, Katsuhiko
Baba, Shingo
Sasaki, Masayuki
author_facet Akamatsu, Go
Tsutsui, Yuji
Daisaki, Hiromitsu
Mitsumoto, Katsuhiko
Baba, Shingo
Sasaki, Masayuki
author_sort Akamatsu, Go
collection PubMed
description PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and physical factors. The variability may have a significant impact on a study outcome. Appropriate scanner calibration and quality control, standardization of imaging protocols, and any necessary harmonization strategies are essential to make use of PET as a biomarker with low bias and variability. This review summarizes benefits, limitations, and remaining challenges for harmonization of quantitative PET, including whole-body PET in oncology, brain PET in neurology, PET/MR, and non-(18)F PET imaging. This review is expected to facilitate harmonization of quantitative PET and to promote the contribution of PET-derived biomarkers to research and development in medicine.
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spelling pubmed-99023322023-02-08 A review of harmonization strategies for quantitative PET Akamatsu, Go Tsutsui, Yuji Daisaki, Hiromitsu Mitsumoto, Katsuhiko Baba, Shingo Sasaki, Masayuki Ann Nucl Med Invited Review Article PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and physical factors. The variability may have a significant impact on a study outcome. Appropriate scanner calibration and quality control, standardization of imaging protocols, and any necessary harmonization strategies are essential to make use of PET as a biomarker with low bias and variability. This review summarizes benefits, limitations, and remaining challenges for harmonization of quantitative PET, including whole-body PET in oncology, brain PET in neurology, PET/MR, and non-(18)F PET imaging. This review is expected to facilitate harmonization of quantitative PET and to promote the contribution of PET-derived biomarkers to research and development in medicine. Springer Nature Singapore 2023-01-06 2023 /pmc/articles/PMC9902332/ /pubmed/36607466 http://dx.doi.org/10.1007/s12149-022-01820-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Invited Review Article
Akamatsu, Go
Tsutsui, Yuji
Daisaki, Hiromitsu
Mitsumoto, Katsuhiko
Baba, Shingo
Sasaki, Masayuki
A review of harmonization strategies for quantitative PET
title A review of harmonization strategies for quantitative PET
title_full A review of harmonization strategies for quantitative PET
title_fullStr A review of harmonization strategies for quantitative PET
title_full_unstemmed A review of harmonization strategies for quantitative PET
title_short A review of harmonization strategies for quantitative PET
title_sort review of harmonization strategies for quantitative pet
topic Invited Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902332/
https://www.ncbi.nlm.nih.gov/pubmed/36607466
http://dx.doi.org/10.1007/s12149-022-01820-x
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