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Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insul...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902351/ https://www.ncbi.nlm.nih.gov/pubmed/36761354 http://dx.doi.org/10.3389/fncel.2023.1094808 |
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author | Shi, Tianyao Feng, Shufang Zhou, Zhonglin Li, Fengan Fu, Yuan Zhou, Wenxia |
author_facet | Shi, Tianyao Feng, Shufang Zhou, Zhonglin Li, Fengan Fu, Yuan Zhou, Wenxia |
author_sort | Shi, Tianyao |
collection | PubMed |
description | Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insular cortex (AIC) is a crucial structure to integrate sensory information with emotional and motivational states. These properties suggest that AIC can influence a subjective prediction in decision-making. In this study, we demonstrated that stressed mice prefer to take more risky choices than control mice using a gambling test. Manipulating the neural activity of AIC or selectively inhibiting the AIC-BLA pathway with chemogenetic intervention resulted in alterations in risk decision-making in mice. Different sexes may have different decision-making strategies in risky situations. Endogenous estrogen levels affect emotional cognition by modulating the stress system function in women. We observed decision-making behavior in mice of different sexes with or without stress experience. The result showed that female mice did not change their choice strategy with increasing risk/reward probability and performed a lower risk preference than male mice after stress. Using the pharmacological method, we bilaterally injected an estrogen receptor (ER) antagonist that resulted in more risky behavior and decreased synaptic plasticity in the AIC of female mice. Our study suggested that the AIC is a crucial region involved in stress-induced alteration of decision-making, and estrogen in the AIC may regulate decision-making behavior by regulating synaptic plasticity. |
format | Online Article Text |
id | pubmed-9902351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99023512023-02-08 Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes Shi, Tianyao Feng, Shufang Zhou, Zhonglin Li, Fengan Fu, Yuan Zhou, Wenxia Front Cell Neurosci Neuroscience Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insular cortex (AIC) is a crucial structure to integrate sensory information with emotional and motivational states. These properties suggest that AIC can influence a subjective prediction in decision-making. In this study, we demonstrated that stressed mice prefer to take more risky choices than control mice using a gambling test. Manipulating the neural activity of AIC or selectively inhibiting the AIC-BLA pathway with chemogenetic intervention resulted in alterations in risk decision-making in mice. Different sexes may have different decision-making strategies in risky situations. Endogenous estrogen levels affect emotional cognition by modulating the stress system function in women. We observed decision-making behavior in mice of different sexes with or without stress experience. The result showed that female mice did not change their choice strategy with increasing risk/reward probability and performed a lower risk preference than male mice after stress. Using the pharmacological method, we bilaterally injected an estrogen receptor (ER) antagonist that resulted in more risky behavior and decreased synaptic plasticity in the AIC of female mice. Our study suggested that the AIC is a crucial region involved in stress-induced alteration of decision-making, and estrogen in the AIC may regulate decision-making behavior by regulating synaptic plasticity. Frontiers Media S.A. 2023-01-24 /pmc/articles/PMC9902351/ /pubmed/36761354 http://dx.doi.org/10.3389/fncel.2023.1094808 Text en Copyright © 2023 Shi, Feng, Zhou, Li, Fu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Shi, Tianyao Feng, Shufang Zhou, Zhonglin Li, Fengan Fu, Yuan Zhou, Wenxia Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title | Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title_full | Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title_fullStr | Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title_full_unstemmed | Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title_short | Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
title_sort | stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902351/ https://www.ncbi.nlm.nih.gov/pubmed/36761354 http://dx.doi.org/10.3389/fncel.2023.1094808 |
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