Cargando…

Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes

Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insul...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Tianyao, Feng, Shufang, Zhou, Zhonglin, Li, Fengan, Fu, Yuan, Zhou, Wenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902351/
https://www.ncbi.nlm.nih.gov/pubmed/36761354
http://dx.doi.org/10.3389/fncel.2023.1094808
_version_ 1784883241343254528
author Shi, Tianyao
Feng, Shufang
Zhou, Zhonglin
Li, Fengan
Fu, Yuan
Zhou, Wenxia
author_facet Shi, Tianyao
Feng, Shufang
Zhou, Zhonglin
Li, Fengan
Fu, Yuan
Zhou, Wenxia
author_sort Shi, Tianyao
collection PubMed
description Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insular cortex (AIC) is a crucial structure to integrate sensory information with emotional and motivational states. These properties suggest that AIC can influence a subjective prediction in decision-making. In this study, we demonstrated that stressed mice prefer to take more risky choices than control mice using a gambling test. Manipulating the neural activity of AIC or selectively inhibiting the AIC-BLA pathway with chemogenetic intervention resulted in alterations in risk decision-making in mice. Different sexes may have different decision-making strategies in risky situations. Endogenous estrogen levels affect emotional cognition by modulating the stress system function in women. We observed decision-making behavior in mice of different sexes with or without stress experience. The result showed that female mice did not change their choice strategy with increasing risk/reward probability and performed a lower risk preference than male mice after stress. Using the pharmacological method, we bilaterally injected an estrogen receptor (ER) antagonist that resulted in more risky behavior and decreased synaptic plasticity in the AIC of female mice. Our study suggested that the AIC is a crucial region involved in stress-induced alteration of decision-making, and estrogen in the AIC may regulate decision-making behavior by regulating synaptic plasticity.
format Online
Article
Text
id pubmed-9902351
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99023512023-02-08 Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes Shi, Tianyao Feng, Shufang Zhou, Zhonglin Li, Fengan Fu, Yuan Zhou, Wenxia Front Cell Neurosci Neuroscience Stress can affect people’s judgment and make them take risky decisions. Abnormal decision-making behavior is a core symptom of psychiatric disorders, such as anxiety, depression, and substance abuse. However, the neuronal mechanisms underlying such impairments are largely unknown. The anterior insular cortex (AIC) is a crucial structure to integrate sensory information with emotional and motivational states. These properties suggest that AIC can influence a subjective prediction in decision-making. In this study, we demonstrated that stressed mice prefer to take more risky choices than control mice using a gambling test. Manipulating the neural activity of AIC or selectively inhibiting the AIC-BLA pathway with chemogenetic intervention resulted in alterations in risk decision-making in mice. Different sexes may have different decision-making strategies in risky situations. Endogenous estrogen levels affect emotional cognition by modulating the stress system function in women. We observed decision-making behavior in mice of different sexes with or without stress experience. The result showed that female mice did not change their choice strategy with increasing risk/reward probability and performed a lower risk preference than male mice after stress. Using the pharmacological method, we bilaterally injected an estrogen receptor (ER) antagonist that resulted in more risky behavior and decreased synaptic plasticity in the AIC of female mice. Our study suggested that the AIC is a crucial region involved in stress-induced alteration of decision-making, and estrogen in the AIC may regulate decision-making behavior by regulating synaptic plasticity. Frontiers Media S.A. 2023-01-24 /pmc/articles/PMC9902351/ /pubmed/36761354 http://dx.doi.org/10.3389/fncel.2023.1094808 Text en Copyright © 2023 Shi, Feng, Zhou, Li, Fu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Shi, Tianyao
Feng, Shufang
Zhou, Zhonglin
Li, Fengan
Fu, Yuan
Zhou, Wenxia
Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title_full Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title_fullStr Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title_full_unstemmed Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title_short Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
title_sort stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902351/
https://www.ncbi.nlm.nih.gov/pubmed/36761354
http://dx.doi.org/10.3389/fncel.2023.1094808
work_keys_str_mv AT shitianyao stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes
AT fengshufang stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes
AT zhouzhonglin stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes
AT lifengan stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes
AT fuyuan stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes
AT zhouwenxia stressalteringanteriorinsularcortexactivityaffectsriskdecisionmakingbehaviorinmiceofdifferentsexes