Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme—A molecular insight (†)

Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the electrophilicity of specific positions of the ligand towards covalent lysine modification. For ligand design, we made use of the advantages o...

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Detalles Bibliográficos
Autores principales: Rodríguez, Ángela, Maneiro, María, Lence, Emilio, Otero, José M., van Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902378/
https://www.ncbi.nlm.nih.gov/pubmed/36762206
http://dx.doi.org/10.3389/fmolb.2023.1111598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902378/
https://www.ncbi.nlm.nih.gov/pubmed/36762206
http://dx.doi.org/10.3389/fmolb.2023.1111598

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