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High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples
Wilms tumor 1 (WT1) is a promising target antigen for cancer immunotherapy. However, WT1 protein expression and its clinical correlation in multiple myeloma (MM) patients are still limited. We, therefore, investigated WT1 expression in 142 bone marrow and plasmacytoma samples of MM patients at diffe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902379/ https://www.ncbi.nlm.nih.gov/pubmed/36760714 http://dx.doi.org/10.3389/pore.2023.1610844 |
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author | Phikulsod, Ployploen Sukpanichnant, Sanya Kunacheewa, Chutima Chieochansin, Thaweesak Junking, Mutita Yenchitsomanus, Pa-Thai |
author_facet | Phikulsod, Ployploen Sukpanichnant, Sanya Kunacheewa, Chutima Chieochansin, Thaweesak Junking, Mutita Yenchitsomanus, Pa-Thai |
author_sort | Phikulsod, Ployploen |
collection | PubMed |
description | Wilms tumor 1 (WT1) is a promising target antigen for cancer immunotherapy. However, WT1 protein expression and its clinical correlation in multiple myeloma (MM) patients are still limited. We, therefore, investigated WT1 expression in 142 bone marrow and plasmacytoma samples of MM patients at different stages of the disease by immunohistochemistry. The correlations between WT1 expression and clinical parameters or treatment outcomes were evaluated. The overall positive rate of WT1 expression was 91.5%; this high prevalence was found in both bone marrow and plasmacytoma samples, regardless of the disease status. Cytoplasmic WT1 expression was correlated with high serum free light chain ratio at presentation. However, no significant association between WT1 expression and treatment outcome was observed. This study confirms the high prevalence of WT1 expression in an Asian cohort of MM, encouraging the development of immunotherapy targeting WT1 in MM patients, particularly in those with extramedullary plasmacytoma or relapsed disease. |
format | Online Article Text |
id | pubmed-9902379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99023792023-02-08 High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples Phikulsod, Ployploen Sukpanichnant, Sanya Kunacheewa, Chutima Chieochansin, Thaweesak Junking, Mutita Yenchitsomanus, Pa-Thai Pathol Oncol Res Pathology and Oncology Archive Wilms tumor 1 (WT1) is a promising target antigen for cancer immunotherapy. However, WT1 protein expression and its clinical correlation in multiple myeloma (MM) patients are still limited. We, therefore, investigated WT1 expression in 142 bone marrow and plasmacytoma samples of MM patients at different stages of the disease by immunohistochemistry. The correlations between WT1 expression and clinical parameters or treatment outcomes were evaluated. The overall positive rate of WT1 expression was 91.5%; this high prevalence was found in both bone marrow and plasmacytoma samples, regardless of the disease status. Cytoplasmic WT1 expression was correlated with high serum free light chain ratio at presentation. However, no significant association between WT1 expression and treatment outcome was observed. This study confirms the high prevalence of WT1 expression in an Asian cohort of MM, encouraging the development of immunotherapy targeting WT1 in MM patients, particularly in those with extramedullary plasmacytoma or relapsed disease. Frontiers Media S.A. 2023-01-24 /pmc/articles/PMC9902379/ /pubmed/36760714 http://dx.doi.org/10.3389/pore.2023.1610844 Text en Copyright © 2023 Phikulsod, Sukpanichnant, Kunacheewa, Chieochansin, Junking and Yenchitsomanus. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pathology and Oncology Archive Phikulsod, Ployploen Sukpanichnant, Sanya Kunacheewa, Chutima Chieochansin, Thaweesak Junking, Mutita Yenchitsomanus, Pa-Thai High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title | High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title_full | High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title_fullStr | High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title_full_unstemmed | High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title_short | High prevalence of Wilms tumor 1 expression in multiple myeloma and plasmacytoma: A cohort of 142 Asian patients’ samples |
title_sort | high prevalence of wilms tumor 1 expression in multiple myeloma and plasmacytoma: a cohort of 142 asian patients’ samples |
topic | Pathology and Oncology Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902379/ https://www.ncbi.nlm.nih.gov/pubmed/36760714 http://dx.doi.org/10.3389/pore.2023.1610844 |
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