Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but f...

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Detalles Bibliográficos
Autores principales: Tanner, L., Single, A. B., Bhongir, R. K. V., Heusel, M., Mohanty, T., Karlsson, C. A. Q., Pan, L., Clausson, C-M., Bergwik, J., Wang, K., Andersson, C. K., Oommen, R. M., Erjefält, J. S., Malmström, J., Wallner, O., Boldogh, I., Helleday, T., Kalderén, C., Egesten, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902543/
https://www.ncbi.nlm.nih.gov/pubmed/36746968
http://dx.doi.org/10.1038/s41467-023-36314-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902543/
https://www.ncbi.nlm.nih.gov/pubmed/36746968
http://dx.doi.org/10.1038/s41467-023-36314-5

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