Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p/sonic hedgehog signaling-regulated stemness

BACKGROUND: Chemotherapy resistance is the major cause of recurrence in patients with colorectal cancer (CRC). A previous study found that Fusobacterium (F.) nucleatum promoted CRC chemoresistance. Additionally, metformin rescued F. nucleatum-induced tumorigenicity of CRC. Here, we aimed to investig...

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Detalles Bibliográficos
Autores principales: Hong, Xia-Lu, Yu, Ta-Chung, Huang, Xiao-Wen, Wang, Ji-Lin, Sun, Tian-Tian, Yan, Ting-Ting, Zhou, Cheng-Bei, Chen, Hui-Min, Su, Wen-Yu, Du, Wan, Xiong, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902563/
https://www.ncbi.nlm.nih.gov/pubmed/36396820
http://dx.doi.org/10.1038/s41416-022-02044-6

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