Cargando…

Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health

Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related nervous system pathologies and neurological decline. The degree to which the neuroprotective effect of DR operates by attenuating cell intrinsic degradative processes rather than influencing non-cell autonomou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Birkisdóttir, María Björk, Van’t Sant, Lisanne J., Brandt, Renata M. C., Barnhoorn, Sander, Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Jaarsma, Dick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902592/ https://www.ncbi.nlm.nih.gov/pubmed/36760711 http://dx.doi.org/10.3389/fnagi.2022.1095801

Ejemplares similares

Gene expression changes in cerebellum induced by dietary restriction
por: van’t Sant, Lisanne J., et al.
Publicado: (2023)

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration
por: van’t Sant, Lisanne J., et al.
Publicado: (2021)

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
por: Birkisdóttir, María B., et al.
Publicado: (2022)

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
por: Birkisdóttir, María B., et al.
Publicado: (2022)

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
por: Birkisdóttir, María B., et al.
Publicado: (2021)

Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness
por: Pieren, Daan K. J., et al.
Publicado: (2021)

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency
por: Barnhoorn, Sander, et al.
Publicado: (2014)

The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons
por: Ding, Mingmei, et al.
Publicado: (2022)

Shapeshifting tau: from intrinsically disordered to paired-helical filaments
por: Mengham, Kurtis, et al.
Publicado: (2022)

Age and Sex Differences in Heart Failure With Preserved Ejection Fraction
por: Kobak, Kamil Aleksander, et al.
Publicado: (2022)

“An Intrinsic Program Determines Key Age-Associated Changes in Adaptive Immunity That Limit Response to Non-Pathogens”
por: Swain, Susan L., et al.
Publicado: (2021)

Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
por: Mayor, Eric
Publicado: (2023)

Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning
por: Galliano, Elisa, et al.
Publicado: (2018)

Region‐specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1
por: White, Joshua J., et al.
Publicado: (2021)

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension
por: Campion, Richard, et al.
Publicado: (2021)

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction
por: Martinez, Wenceslao, et al.
Publicado: (2022)

The intrinsic and synaptic responsiveness of a new realistic Purkinje cell model
por: Masoli, Stefano, et al.
Publicado: (2013)

Growth Differentiation Factor-15 in Immunity and Aging
por: Pence, Brandt D.
Publicado: (2022)

Decreased intrinsic excitability of cerebellar Purkinje cells following optokinetic learning in mice
por: Kim, Yong Gyu, et al.
Publicado: (2020)

Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones
por: Viet, Nguyen-Minh, et al.
Publicado: (2021)

Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
por: Lin, Ting-Feng, et al.
Publicado: (2023)

The Predictive Value of Dynamic Intrinsic Local Metrics in Transient Ischemic Attack
por: Ma, Huibin, et al.
Publicado: (2022)

Stem Cells in the Myelodysplastic Syndromes
por: Zhan, Di, et al.
Publicado: (2021)

Lysosomes in T Cell Immunity and Aging
por: Jin, Jun, et al.
Publicado: (2021)

The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning
por: Shim, Hyun Geun, et al.
Publicado: (2018)

Diminished Pneumococcal-Specific CD4(+) T-Cell Response is Associated With Increased Regulatory T Cells at Older Age
por: He, Samantha W. J., et al.
Publicado: (2021)

Single cell analysis of transcriptome and open chromatin reveals the dynamics of hair follicle stem cell aging
por: Zhang, Chi, et al.
Publicado: (2023)

An NRF2 Perspective on Stem Cells and Ageing
por: Dodson, Matthew, et al.
Publicado: (2021)

T-Cell Aging-Associated Phenotypes in Autoimmune Disease
por: Zhao, Tuantuan V., et al.
Publicado: (2022)

Oocyte aging in comparison to stem cells in mice
por: Nagamatsu, Go
Publicado: (2023)

Simple Detection Methods for Senescent Cells: Opportunities and Challenges
por: Faragher, Richard G. A.
Publicado: (2021)

Induction of T Cell Senescence by Cytokine Induced Bystander Activation
por: Abbas, Attiya A., et al.
Publicado: (2021)

Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites
por: Ohtsuki, Gen
Publicado: (2020)

Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation
por: Jang, Dong Cheol, et al.
Publicado: (2023)

Disease-gene prediction based on preserving structure network embedding
por: Ma, Jinlong, et al.
Publicado: (2023)

Age-Associated Changes to Lymph Node Fibroblastic Reticular Cells
por: Kwok, Tina, et al.
Publicado: (2022)

The influence of three-dimensional structure on naïve T cell homeostasis and aging
por: Lambert, Simon, et al.
Publicado: (2022)

Intrinsic Brain Activity of Inferior Temporal Region Increased in Prodromal Alzheimer's Disease With Hearing Loss
por: Hong, Luwei, et al.
Publicado: (2022)

Activity-homeostasis preserves synaptic plasticity in Purkinje cell but calcium is not the activity-sensor
por: Achard, Pablo, et al.
Publicado: (2007)

Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data
por: Huang, August Yue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_icosboi4s1adfp25iotb4140gh