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Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Nephrology
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902730/ https://www.ncbi.nlm.nih.gov/pubmed/36747358 http://dx.doi.org/10.23876/j.krcp.22.042 |
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author | Ryu, Jiwon Baek, Eunji Son, Hyung-Eun Ryu, Ji-Young Jeong, Jong Cheol Kim, Sejoong Na, Ki Young Chae, Dong-Wan Kim, Seong Pyo Kim, Su Hwan Jhee, Jong Hyun Chang, Tae Ik Choi, Bum Soon Chin, Ho Jun |
author_facet | Ryu, Jiwon Baek, Eunji Son, Hyung-Eun Ryu, Ji-Young Jeong, Jong Cheol Kim, Sejoong Na, Ki Young Chae, Dong-Wan Kim, Seong Pyo Kim, Su Hwan Jhee, Jong Hyun Chang, Tae Ik Choi, Bum Soon Chin, Ho Jun |
author_sort | Ryu, Jiwon |
collection | PubMed |
description | BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. RESULTS: The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of <60 mL/min/1.72 m(2) (p ≤ 0.001), higher (but not significantly so) C-reactive protein level, and lower serum C3 level (p ≤ 0.001). Serum albumin, urine protein/creatinine ratio, number of patients who progressed to end-stage renal disease, and all-cause mortality were comparable between groups. Interstitial fibrosis and mesangial cellularity were greater in the C3D-GN group (p = 0.04 and p = 0.01, respectively) than in the C3ND-GN group. C3 deposition was dominant in the former group (p < 0.001), in parallel with increased subendothelial deposition (p ≤ 0.001). CONCLUSION: Greater progression of renal injury and higher mortality occurred in patients with C3D-GN than with C3ND-GN, along with pathologic differences in interstitial and mesangial changes. |
format | Online Article Text |
id | pubmed-9902730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-99027302023-02-16 Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis Ryu, Jiwon Baek, Eunji Son, Hyung-Eun Ryu, Ji-Young Jeong, Jong Cheol Kim, Sejoong Na, Ki Young Chae, Dong-Wan Kim, Seong Pyo Kim, Su Hwan Jhee, Jong Hyun Chang, Tae Ik Choi, Bum Soon Chin, Ho Jun Kidney Res Clin Pract Original Article BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. RESULTS: The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of <60 mL/min/1.72 m(2) (p ≤ 0.001), higher (but not significantly so) C-reactive protein level, and lower serum C3 level (p ≤ 0.001). Serum albumin, urine protein/creatinine ratio, number of patients who progressed to end-stage renal disease, and all-cause mortality were comparable between groups. Interstitial fibrosis and mesangial cellularity were greater in the C3D-GN group (p = 0.04 and p = 0.01, respectively) than in the C3ND-GN group. C3 deposition was dominant in the former group (p < 0.001), in parallel with increased subendothelial deposition (p ≤ 0.001). CONCLUSION: Greater progression of renal injury and higher mortality occurred in patients with C3D-GN than with C3ND-GN, along with pathologic differences in interstitial and mesangial changes. The Korean Society of Nephrology 2023-01 2023-01-31 /pmc/articles/PMC9902730/ /pubmed/36747358 http://dx.doi.org/10.23876/j.krcp.22.042 Text en Copyright © 2023 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited. |
spellingShingle | Original Article Ryu, Jiwon Baek, Eunji Son, Hyung-Eun Ryu, Ji-Young Jeong, Jong Cheol Kim, Sejoong Na, Ki Young Chae, Dong-Wan Kim, Seong Pyo Kim, Su Hwan Jhee, Jong Hyun Chang, Tae Ik Choi, Bum Soon Chin, Ho Jun Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title_full | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title_fullStr | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title_full_unstemmed | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title_short | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis |
title_sort | comparison of dominant and nondominant c3 deposition in primary glomerulonephritis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902730/ https://www.ncbi.nlm.nih.gov/pubmed/36747358 http://dx.doi.org/10.23876/j.krcp.22.042 |
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