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Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis

BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We...

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Autores principales: Ryu, Jiwon, Baek, Eunji, Son, Hyung-Eun, Ryu, Ji-Young, Jeong, Jong Cheol, Kim, Sejoong, Na, Ki Young, Chae, Dong-Wan, Kim, Seong Pyo, Kim, Su Hwan, Jhee, Jong Hyun, Chang, Tae Ik, Choi, Bum Soon, Chin, Ho Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Nephrology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902730/
https://www.ncbi.nlm.nih.gov/pubmed/36747358
http://dx.doi.org/10.23876/j.krcp.22.042
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author Ryu, Jiwon
Baek, Eunji
Son, Hyung-Eun
Ryu, Ji-Young
Jeong, Jong Cheol
Kim, Sejoong
Na, Ki Young
Chae, Dong-Wan
Kim, Seong Pyo
Kim, Su Hwan
Jhee, Jong Hyun
Chang, Tae Ik
Choi, Bum Soon
Chin, Ho Jun
author_facet Ryu, Jiwon
Baek, Eunji
Son, Hyung-Eun
Ryu, Ji-Young
Jeong, Jong Cheol
Kim, Sejoong
Na, Ki Young
Chae, Dong-Wan
Kim, Seong Pyo
Kim, Su Hwan
Jhee, Jong Hyun
Chang, Tae Ik
Choi, Bum Soon
Chin, Ho Jun
author_sort Ryu, Jiwon
collection PubMed
description BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. RESULTS: The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of <60 mL/min/1.72 m(2) (p ≤ 0.001), higher (but not significantly so) C-reactive protein level, and lower serum C3 level (p ≤ 0.001). Serum albumin, urine protein/creatinine ratio, number of patients who progressed to end-stage renal disease, and all-cause mortality were comparable between groups. Interstitial fibrosis and mesangial cellularity were greater in the C3D-GN group (p = 0.04 and p = 0.01, respectively) than in the C3ND-GN group. C3 deposition was dominant in the former group (p < 0.001), in parallel with increased subendothelial deposition (p ≤ 0.001). CONCLUSION: Greater progression of renal injury and higher mortality occurred in patients with C3D-GN than with C3ND-GN, along with pathologic differences in interstitial and mesangial changes.
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spelling pubmed-99027302023-02-16 Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis Ryu, Jiwon Baek, Eunji Son, Hyung-Eun Ryu, Ji-Young Jeong, Jong Cheol Kim, Sejoong Na, Ki Young Chae, Dong-Wan Kim, Seong Pyo Kim, Su Hwan Jhee, Jong Hyun Chang, Tae Ik Choi, Bum Soon Chin, Ho Jun Kidney Res Clin Pract Original Article BACKGROUND: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. METHODS: We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. RESULTS: The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of <60 mL/min/1.72 m(2) (p ≤ 0.001), higher (but not significantly so) C-reactive protein level, and lower serum C3 level (p ≤ 0.001). Serum albumin, urine protein/creatinine ratio, number of patients who progressed to end-stage renal disease, and all-cause mortality were comparable between groups. Interstitial fibrosis and mesangial cellularity were greater in the C3D-GN group (p = 0.04 and p = 0.01, respectively) than in the C3ND-GN group. C3 deposition was dominant in the former group (p < 0.001), in parallel with increased subendothelial deposition (p ≤ 0.001). CONCLUSION: Greater progression of renal injury and higher mortality occurred in patients with C3D-GN than with C3ND-GN, along with pathologic differences in interstitial and mesangial changes. The Korean Society of Nephrology 2023-01 2023-01-31 /pmc/articles/PMC9902730/ /pubmed/36747358 http://dx.doi.org/10.23876/j.krcp.22.042 Text en Copyright © 2023 The Korean Society of Nephrology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial and No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) which permits unrestricted non-commercial use, distribution of the material without any modifications, and reproduction in any medium, provided the original works properly cited.
spellingShingle Original Article
Ryu, Jiwon
Baek, Eunji
Son, Hyung-Eun
Ryu, Ji-Young
Jeong, Jong Cheol
Kim, Sejoong
Na, Ki Young
Chae, Dong-Wan
Kim, Seong Pyo
Kim, Su Hwan
Jhee, Jong Hyun
Chang, Tae Ik
Choi, Bum Soon
Chin, Ho Jun
Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title_full Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title_fullStr Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title_full_unstemmed Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title_short Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
title_sort comparison of dominant and nondominant c3 deposition in primary glomerulonephritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902730/
https://www.ncbi.nlm.nih.gov/pubmed/36747358
http://dx.doi.org/10.23876/j.krcp.22.042
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