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Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease associated with impaired organ functions that can seriously affect the daily life of patients. Recent SLE therapies frequently elicit adverse reactions and side effects in patients, and clinical heterogeneity is considerable...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903023/ https://www.ncbi.nlm.nih.gov/pubmed/36661068 http://dx.doi.org/10.1177/09636897221148775 |
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author | Liu, Yi-jing Miao, Hai-bing Lin, Shu Chen, Zhen |
author_facet | Liu, Yi-jing Miao, Hai-bing Lin, Shu Chen, Zhen |
author_sort | Liu, Yi-jing |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease associated with impaired organ functions that can seriously affect the daily life of patients. Recent SLE therapies frequently elicit adverse reactions and side effects in patients, and clinical heterogeneity is considerable. Mesenchymal stromal cells (MSCs) have anti-inflammatory, tissue repair, and immunomodulatory properties. Their ability to treat autoimmune diseases largely depends on secreted extracellular vesicles, especially exosomes. The effects of exosomes and microRNAs (miRNAs) on SLE have recently attracted interest. This review summarizes the applications of MSCs derived from bone marrow, adipocyte tissue, umbilical cord, synovial membrane, and gingival tissue, as well as exosomes to treating SLE and the key roles of miRNAs. The efficacy of MSCs infusion in SLE patients with impaired autologous MSCs are reviewed, and the potential of exosomes and their contents as drug delivery vectors for treating SLE and other autoimmune diseases in the future are briefly described. |
format | Online Article Text |
id | pubmed-9903023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-99030232023-02-08 Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs Liu, Yi-jing Miao, Hai-bing Lin, Shu Chen, Zhen Cell Transplant Review Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease associated with impaired organ functions that can seriously affect the daily life of patients. Recent SLE therapies frequently elicit adverse reactions and side effects in patients, and clinical heterogeneity is considerable. Mesenchymal stromal cells (MSCs) have anti-inflammatory, tissue repair, and immunomodulatory properties. Their ability to treat autoimmune diseases largely depends on secreted extracellular vesicles, especially exosomes. The effects of exosomes and microRNAs (miRNAs) on SLE have recently attracted interest. This review summarizes the applications of MSCs derived from bone marrow, adipocyte tissue, umbilical cord, synovial membrane, and gingival tissue, as well as exosomes to treating SLE and the key roles of miRNAs. The efficacy of MSCs infusion in SLE patients with impaired autologous MSCs are reviewed, and the potential of exosomes and their contents as drug delivery vectors for treating SLE and other autoimmune diseases in the future are briefly described. SAGE Publications 2023-01-20 /pmc/articles/PMC9903023/ /pubmed/36661068 http://dx.doi.org/10.1177/09636897221148775 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Liu, Yi-jing Miao, Hai-bing Lin, Shu Chen, Zhen Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title | Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title_full | Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title_fullStr | Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title_full_unstemmed | Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title_short | Current Progress in Treating Systemic Lupus Erythematosus Using Exosomes/MicroRNAs |
title_sort | current progress in treating systemic lupus erythematosus using exosomes/micrornas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903023/ https://www.ncbi.nlm.nih.gov/pubmed/36661068 http://dx.doi.org/10.1177/09636897221148775 |
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