Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells

BACKGROUND: Epithelial-mesenchymal-transition (EMT) is an epigenetic-based mechanism contributing to the acquired treatment resistance against receptor tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) cells harboring epidermal growth factor receptor (EGFR)-mutations. Delineati...

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Detalles Bibliográficos
Autores principales: Vad-Nielsen, Johan, Staunstrup, Nicklas Heine, Kjeldsen, Magnus Lindkvist, Dybdal, Nina, Flandin, Guillaume, De Stradis, Claudia, Daugaard, Tina Fuglsang, Vilsbøll-Larsen, Trine, Maansson, Christoffer Trier, Doktor, Thomas Koed, Sorensen, Boe Sandahl, Nielsen, Anders Lade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903082/
https://www.ncbi.nlm.nih.gov/pubmed/36762066
http://dx.doi.org/10.21037/tlcr-22-507

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