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Selective decrease in alpha(1)-antitrypsin levels in diabetic retinopathy: Could the levels of it be playing a role in the pathophysiology of diabetic retinopathy?
BACKGROUND & OBJECTIVES: Type 2 diabetes mellitus (T2DM) is known to induce inflammation and activation of neutrophils causing the release of neutrophil elastase (NE), a pro-inflammatory proteinase. The activity of NE is regulated by endogenous inhibitors alpha(1)-antitrypsin (α(1)-AT) and alpha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903389/ https://www.ncbi.nlm.nih.gov/pubmed/36124492 http://dx.doi.org/10.4103/ijmr.IJMR_1293_19 |