Cargando…

Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation

[Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers h...

Descripción completa

Detalles Bibliográficos
Autores principales: Maisto, Antonio, McDowall, Daniel, Adams, Dave J., Del Giudice, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903399/
http://dx.doi.org/10.1021/acsaenm.2c00060
_version_ 1784883464847228928
author Maisto, Antonio
McDowall, Daniel
Adams, Dave J.
Del Giudice, Francesco
author_facet Maisto, Antonio
McDowall, Daniel
Adams, Dave J.
Del Giudice, Francesco
author_sort Maisto, Antonio
collection PubMed
description [Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields.
format Online
Article
Text
id pubmed-9903399
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-99033992023-02-08 Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation Maisto, Antonio McDowall, Daniel Adams, Dave J. Del Giudice, Francesco ACS Appl Eng Mater [Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields. American Chemical Society 2022-09-23 /pmc/articles/PMC9903399/ http://dx.doi.org/10.1021/acsaenm.2c00060 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Maisto, Antonio
McDowall, Daniel
Adams, Dave J.
Del Giudice, Francesco
Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_full Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_fullStr Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_full_unstemmed Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_short Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
title_sort continuous manufacturing of microfluidic fibers embedded with ordered microparticles via ionic gelation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903399/
http://dx.doi.org/10.1021/acsaenm.2c00060
work_keys_str_mv AT maistoantonio continuousmanufacturingofmicrofluidicfibersembeddedwithorderedmicroparticlesviaionicgelation
AT mcdowalldaniel continuousmanufacturingofmicrofluidicfibersembeddedwithorderedmicroparticlesviaionicgelation
AT adamsdavej continuousmanufacturingofmicrofluidicfibersembeddedwithorderedmicroparticlesviaionicgelation
AT delgiudicefrancesco continuousmanufacturingofmicrofluidicfibersembeddedwithorderedmicroparticlesviaionicgelation