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Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation
[Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903399/ http://dx.doi.org/10.1021/acsaenm.2c00060 |
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author | Maisto, Antonio McDowall, Daniel Adams, Dave J. Del Giudice, Francesco |
author_facet | Maisto, Antonio McDowall, Daniel Adams, Dave J. Del Giudice, Francesco |
author_sort | Maisto, Antonio |
collection | PubMed |
description | [Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields. |
format | Online Article Text |
id | pubmed-9903399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99033992023-02-08 Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation Maisto, Antonio McDowall, Daniel Adams, Dave J. Del Giudice, Francesco ACS Appl Eng Mater [Image: see text] Fibers loaded with either particles or cells are widely employed across a variety of fields, including material science, tissue engineering, and pharmaceutical research. However, the concentration of such objects along the fiber length remains stochastic, thus resulting in fibers having heterogeneous properties along their length. We here introduce a new class of material featuring fibers loaded with “equally spaced” microparticles. The fibers were obtained thanks to the combination between the recently discovered viscoelastic particle ordering phenomenon and the well-established process of fiber synthesis via ex situ ionic gelation. We employed a simple experimental apparatus made of a syringe pump connected to a 100 μm tube ending in a calcium chloride bath. The liquid forming the fiber was an aqueous solution of hyaluronic acid and sodium alginate. We studied the effect of volumetric flow rate, sodium alginate concentration, and spinning speed on the fiber diameter and the particle-spacing in the fiber. We also discussed the advantages of this type of fiber over the existing ones and suggested potential applications across several fields. American Chemical Society 2022-09-23 /pmc/articles/PMC9903399/ http://dx.doi.org/10.1021/acsaenm.2c00060 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Maisto, Antonio McDowall, Daniel Adams, Dave J. Del Giudice, Francesco Continuous Manufacturing of Microfluidic Fibers Embedded with Ordered Microparticles via Ionic Gelation |
title | Continuous Manufacturing
of Microfluidic Fibers Embedded
with Ordered Microparticles via Ionic Gelation |
title_full | Continuous Manufacturing
of Microfluidic Fibers Embedded
with Ordered Microparticles via Ionic Gelation |
title_fullStr | Continuous Manufacturing
of Microfluidic Fibers Embedded
with Ordered Microparticles via Ionic Gelation |
title_full_unstemmed | Continuous Manufacturing
of Microfluidic Fibers Embedded
with Ordered Microparticles via Ionic Gelation |
title_short | Continuous Manufacturing
of Microfluidic Fibers Embedded
with Ordered Microparticles via Ionic Gelation |
title_sort | continuous manufacturing
of microfluidic fibers embedded
with ordered microparticles via ionic gelation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903399/ http://dx.doi.org/10.1021/acsaenm.2c00060 |
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