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Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis
BACKGROUND: The risk factors for osteoporosis and its prognostic value in patients with bronchiectasis is not well characterized. We explored the risk factors for osteoporosis and its prognostic impact in hospitalized non-cystic fibrosis bronchiectasis (NCFB) patients in Southeast China. METHODS: Th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903403/ https://www.ncbi.nlm.nih.gov/pubmed/36747237 http://dx.doi.org/10.1186/s12890-023-02346-2 |
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author | Zou, Xin Ma, Zhiyi Liu, Xiaohong Zhang, Kaijun Qiu, Chenchen Liang, Rongzhang Weng, Duanli Xie, Lingyan Cao, Xiaoming Wu, Yongquan Wen, Liwen |
author_facet | Zou, Xin Ma, Zhiyi Liu, Xiaohong Zhang, Kaijun Qiu, Chenchen Liang, Rongzhang Weng, Duanli Xie, Lingyan Cao, Xiaoming Wu, Yongquan Wen, Liwen |
author_sort | Zou, Xin |
collection | PubMed |
description | BACKGROUND: The risk factors for osteoporosis and its prognostic value in patients with bronchiectasis is not well characterized. We explored the risk factors for osteoporosis and its prognostic impact in hospitalized non-cystic fibrosis bronchiectasis (NCFB) patients in Southeast China. METHODS: This observational cohort study consecutively enrolled 179 hospitalized patients with NCFB bronchiectasis between 2017 and 2021. The risk factors and the impact of osteoporosis on all-cause mortality were assessed. RESULTS: 21.2% (38/179) of hospitalized NCFB patients were diagnosed with osteoporosis. Patients with osteoporosis had more severe symptoms (assessed by chronic airway assessment test, CAT, median 22 vs. 17, P = 0.017), poorer quality of life (assessed by St. George Respiratory Questionnaires, SQRC, median 42 vs. 27, P = 0.007), more severe disease stage (assessed by bronchiectasis severity index, BSI, median 14 vs. 11, P = 0.02), more comorbidities (assessed by Bronchiectasis Aetiology Comorbidity Index, BACI, median 5 vs. 4, P = 0.021) than patients without. Age, female sex, anemia, post-infection, and history of regular inhaled corticosteroid treatment were independent risk factors for osteoporosis in those patients. 21 patients (11.7%) died over a median follow-up period of 32 months. The all-cause mortality in NCFB patients with osteoporosis [28.94% (11/38)] was significantly higher than those without osteoporosis [7.09% (10/141)] [hazard ratio (HR) 5.34, 95% confidence interval (CI) 2.26–12.67, P < 0.001]. After adjusting for BSI and other confounding factors, osteoporosis was still independently associated with all-cause mortality in hospitalized NCFB patients (HR 4.29, 95% CI 1.75–10.49, P < 0.001). CONCLUSIONS: Osteoporosis had an independent effect on all-cause mortality in hospitalized NCFB patients. Management of comorbidities, including bone health, is a critical aspect of treating NCFB patients. |
format | Online Article Text |
id | pubmed-9903403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99034032023-02-08 Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis Zou, Xin Ma, Zhiyi Liu, Xiaohong Zhang, Kaijun Qiu, Chenchen Liang, Rongzhang Weng, Duanli Xie, Lingyan Cao, Xiaoming Wu, Yongquan Wen, Liwen BMC Pulm Med Research BACKGROUND: The risk factors for osteoporosis and its prognostic value in patients with bronchiectasis is not well characterized. We explored the risk factors for osteoporosis and its prognostic impact in hospitalized non-cystic fibrosis bronchiectasis (NCFB) patients in Southeast China. METHODS: This observational cohort study consecutively enrolled 179 hospitalized patients with NCFB bronchiectasis between 2017 and 2021. The risk factors and the impact of osteoporosis on all-cause mortality were assessed. RESULTS: 21.2% (38/179) of hospitalized NCFB patients were diagnosed with osteoporosis. Patients with osteoporosis had more severe symptoms (assessed by chronic airway assessment test, CAT, median 22 vs. 17, P = 0.017), poorer quality of life (assessed by St. George Respiratory Questionnaires, SQRC, median 42 vs. 27, P = 0.007), more severe disease stage (assessed by bronchiectasis severity index, BSI, median 14 vs. 11, P = 0.02), more comorbidities (assessed by Bronchiectasis Aetiology Comorbidity Index, BACI, median 5 vs. 4, P = 0.021) than patients without. Age, female sex, anemia, post-infection, and history of regular inhaled corticosteroid treatment were independent risk factors for osteoporosis in those patients. 21 patients (11.7%) died over a median follow-up period of 32 months. The all-cause mortality in NCFB patients with osteoporosis [28.94% (11/38)] was significantly higher than those without osteoporosis [7.09% (10/141)] [hazard ratio (HR) 5.34, 95% confidence interval (CI) 2.26–12.67, P < 0.001]. After adjusting for BSI and other confounding factors, osteoporosis was still independently associated with all-cause mortality in hospitalized NCFB patients (HR 4.29, 95% CI 1.75–10.49, P < 0.001). CONCLUSIONS: Osteoporosis had an independent effect on all-cause mortality in hospitalized NCFB patients. Management of comorbidities, including bone health, is a critical aspect of treating NCFB patients. BioMed Central 2023-02-06 /pmc/articles/PMC9903403/ /pubmed/36747237 http://dx.doi.org/10.1186/s12890-023-02346-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zou, Xin Ma, Zhiyi Liu, Xiaohong Zhang, Kaijun Qiu, Chenchen Liang, Rongzhang Weng, Duanli Xie, Lingyan Cao, Xiaoming Wu, Yongquan Wen, Liwen Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title | Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title_full | Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title_fullStr | Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title_full_unstemmed | Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title_short | Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
title_sort | risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903403/ https://www.ncbi.nlm.nih.gov/pubmed/36747237 http://dx.doi.org/10.1186/s12890-023-02346-2 |
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