Cargando…

The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses

BACKGROUND: The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Bazrafshani, Maliheh Sadat, Pardakhty, Abbas, Kalantari Khandani, Behjat, Tajadini, Haleh, Ghazanfari Pour, Sadra, Hashemi, Sara, Amiri, Shiva, Mehmandoost, Soheil, Beigzadeh, Amin, Abbaszadeh, Samaneh, Sharifi, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903537/
https://www.ncbi.nlm.nih.gov/pubmed/36750849
http://dx.doi.org/10.1186/s12906-023-03869-1
_version_ 1784883491650928640
author Bazrafshani, Maliheh Sadat
Pardakhty, Abbas
Kalantari Khandani, Behjat
Tajadini, Haleh
Ghazanfari Pour, Sadra
Hashemi, Sara
Amiri, Shiva
Mehmandoost, Soheil
Beigzadeh, Amin
Abbaszadeh, Samaneh
Sharifi, Hamid
author_facet Bazrafshani, Maliheh Sadat
Pardakhty, Abbas
Kalantari Khandani, Behjat
Tajadini, Haleh
Ghazanfari Pour, Sadra
Hashemi, Sara
Amiri, Shiva
Mehmandoost, Soheil
Beigzadeh, Amin
Abbaszadeh, Samaneh
Sharifi, Hamid
author_sort Bazrafshani, Maliheh Sadat
collection PubMed
description BACKGROUND: The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions for cancer patients. METHODS: This cross-sectional study was conducted among a convenience sample of 315 cancer patients referring to the oncology clinics of Kerman city in 2018. Data were collected via comprehensive face-to-face interviews and medical chart reviews. A drug interaction checker was used to determine herb-drug interactions. The information of patients was compared based on herb-drug interactions using bivariable logistic regression models, and predictors were determined by the multivariable logistic regression model. All analyses were performed by Stata software version 16. RESULTS: Of 262 patients (83.2% of the patients) who used herbal medicines, 209 patients [79.8% (95% Confidence Intervals (CI): 75.2 – 85.1)] had potential herb-drug interactions. Chamomile was the most popular herbal medicine (n = 163, 78.0%), and minor and moderate herb-drug interactions were caused by green tea (n = 34, 16.3%) and peppermint (n = 78, 37.5%). The number of chemotherapeutic agents (OR: 1.92, 95% CI: 1.43–2.58; P-value < 0.0001) and the experienced of pain during chemotherapy courses (OR = 2.22, 95%CI:1.00–4.94; P-value = 0.04) were some of the predictors of herb-drug interactions among cancer patients. CONCLUSION: Herbal medicine use during chemotherapy was found prevalent among cancer patients; of them, the experience of potential herb-drug interactions was highly frequent. Oncologists and clinical pharmacologists are recommended to take into account challenges associated with herb-drug interactions in their routine practices, particularly during chemotherapy among these patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-023-03869-1.
format Online
Article
Text
id pubmed-9903537
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-99035372023-02-08 The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses Bazrafshani, Maliheh Sadat Pardakhty, Abbas Kalantari Khandani, Behjat Tajadini, Haleh Ghazanfari Pour, Sadra Hashemi, Sara Amiri, Shiva Mehmandoost, Soheil Beigzadeh, Amin Abbaszadeh, Samaneh Sharifi, Hamid BMC Complement Med Ther Research BACKGROUND: The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions for cancer patients. METHODS: This cross-sectional study was conducted among a convenience sample of 315 cancer patients referring to the oncology clinics of Kerman city in 2018. Data were collected via comprehensive face-to-face interviews and medical chart reviews. A drug interaction checker was used to determine herb-drug interactions. The information of patients was compared based on herb-drug interactions using bivariable logistic regression models, and predictors were determined by the multivariable logistic regression model. All analyses were performed by Stata software version 16. RESULTS: Of 262 patients (83.2% of the patients) who used herbal medicines, 209 patients [79.8% (95% Confidence Intervals (CI): 75.2 – 85.1)] had potential herb-drug interactions. Chamomile was the most popular herbal medicine (n = 163, 78.0%), and minor and moderate herb-drug interactions were caused by green tea (n = 34, 16.3%) and peppermint (n = 78, 37.5%). The number of chemotherapeutic agents (OR: 1.92, 95% CI: 1.43–2.58; P-value < 0.0001) and the experienced of pain during chemotherapy courses (OR = 2.22, 95%CI:1.00–4.94; P-value = 0.04) were some of the predictors of herb-drug interactions among cancer patients. CONCLUSION: Herbal medicine use during chemotherapy was found prevalent among cancer patients; of them, the experience of potential herb-drug interactions was highly frequent. Oncologists and clinical pharmacologists are recommended to take into account challenges associated with herb-drug interactions in their routine practices, particularly during chemotherapy among these patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12906-023-03869-1. BioMed Central 2023-02-07 /pmc/articles/PMC9903537/ /pubmed/36750849 http://dx.doi.org/10.1186/s12906-023-03869-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bazrafshani, Maliheh Sadat
Pardakhty, Abbas
Kalantari Khandani, Behjat
Tajadini, Haleh
Ghazanfari Pour, Sadra
Hashemi, Sara
Amiri, Shiva
Mehmandoost, Soheil
Beigzadeh, Amin
Abbaszadeh, Samaneh
Sharifi, Hamid
The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title_full The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title_fullStr The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title_full_unstemmed The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title_short The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses
title_sort prevalence and predictors of herb-drug interactions among iranian cancer patients during chemotherapy courses
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903537/
https://www.ncbi.nlm.nih.gov/pubmed/36750849
http://dx.doi.org/10.1186/s12906-023-03869-1
work_keys_str_mv AT bazrafshanimalihehsadat theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT pardakhtyabbas theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT kalantarikhandanibehjat theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT tajadinihaleh theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT ghazanfaripoursadra theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT hashemisara theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT amirishiva theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT mehmandoostsoheil theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT beigzadehamin theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT abbaszadehsamaneh theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT sharifihamid theprevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT bazrafshanimalihehsadat prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT pardakhtyabbas prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT kalantarikhandanibehjat prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT tajadinihaleh prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT ghazanfaripoursadra prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT hashemisara prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT amirishiva prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT mehmandoostsoheil prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT beigzadehamin prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT abbaszadehsamaneh prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses
AT sharifihamid prevalenceandpredictorsofherbdruginteractionsamongiraniancancerpatientsduringchemotherapycourses