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Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma

Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these data to develop a CRISPR interference (CRISPRi)-based therapeutic...

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Detalles Bibliográficos
Autores principales:	Koh, Kyung Duk, Bonser, Luke R., Eckalbar, Walter L., Yizhar-Barnea, Ofer, Shen, Jiangshan, Zeng, Xiaoning, Hargett, Kirsten L., Sun, Dingyuan I., Zlock, Lorna T., Finkbeiner, Walter E., Ahituv, Nadav, Erle, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903679/ https://www.ncbi.nlm.nih.gov/pubmed/36777184 http://dx.doi.org/10.1016/j.xgen.2022.100229

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