A template for multitudes: Germline immune polymorphism of the T cell receptor loci

Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. In this issue of Cell Genomics, Rodriguez et al.(1) describe how a probe-based hybrid capture approach coupled with long-re...

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Detalles Bibliográficos
Autor principal: Gragert, Loren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903699/
https://www.ncbi.nlm.nih.gov/pubmed/36778048
http://dx.doi.org/10.1016/j.xgen.2022.100231
Descripción
Sumario:Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. In this issue of Cell Genomics, Rodriguez et al.(1) describe how a probe-based hybrid capture approach coupled with long-read sequencing can resolve fully phased TCR locus haplotypes from diploid human genomes.

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