A template for multitudes: Germline immune polymorphism of the T cell receptor loci

Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. In this issue of Cell Genomics, Rodriguez et al.(1) describe how a probe-based hybrid capture approach coupled with long-re...

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Detalles Bibliográficos
Autor principal: Gragert, Loren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903699/
https://www.ncbi.nlm.nih.gov/pubmed/36778048
http://dx.doi.org/10.1016/j.xgen.2022.100231
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author Gragert, Loren
author_facet Gragert, Loren
author_sort Gragert, Loren
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description Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. In this issue of Cell Genomics, Rodriguez et al.(1) describe how a probe-based hybrid capture approach coupled with long-read sequencing can resolve fully phased TCR locus haplotypes from diploid human genomes.
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spelling pubmed-99036992023-02-10 A template for multitudes: Germline immune polymorphism of the T cell receptor loci Gragert, Loren Cell Genom Preview Short-read next-generation sequencing has failed to adequately genotype the T cell receptor (TCR) loci, limiting our ability to characterize the role of germline TCR variation. In this issue of Cell Genomics, Rodriguez et al.(1) describe how a probe-based hybrid capture approach coupled with long-read sequencing can resolve fully phased TCR locus haplotypes from diploid human genomes. Elsevier 2022-12-14 /pmc/articles/PMC9903699/ /pubmed/36778048 http://dx.doi.org/10.1016/j.xgen.2022.100231 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preview
Gragert, Loren
A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title_full A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title_fullStr A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title_full_unstemmed A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title_short A template for multitudes: Germline immune polymorphism of the T cell receptor loci
title_sort template for multitudes: germline immune polymorphism of the t cell receptor loci
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903699/
https://www.ncbi.nlm.nih.gov/pubmed/36778048
http://dx.doi.org/10.1016/j.xgen.2022.100231
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