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Polygenic score development in the era of large-scale biobanks
In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clini...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903709/ https://www.ncbi.nlm.nih.gov/pubmed/36777037 http://dx.doi.org/10.1016/j.xgen.2021.100088 |
| _version_ | 1784883515671707648 |
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| author | Plagnol, Vincent |
| author_facet | Plagnol, Vincent |
| author_sort | Plagnol, Vincent |
| collection | PubMed |
| description | In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction. |
| format | Online Article Text |
| id | pubmed-9903709 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99037092023-02-10 Polygenic score development in the era of large-scale biobanks Plagnol, Vincent Cell Genom Preview In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction. Elsevier 2022-01-13 /pmc/articles/PMC9903709/ /pubmed/36777037 http://dx.doi.org/10.1016/j.xgen.2021.100088 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Plagnol, Vincent Polygenic score development in the era of large-scale biobanks |
| title | Polygenic score development in the era of large-scale biobanks |
| title_full | Polygenic score development in the era of large-scale biobanks |
| title_fullStr | Polygenic score development in the era of large-scale biobanks |
| title_full_unstemmed | Polygenic score development in the era of large-scale biobanks |
| title_short | Polygenic score development in the era of large-scale biobanks |
| title_sort | polygenic score development in the era of large-scale biobanks |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903709/ https://www.ncbi.nlm.nih.gov/pubmed/36777037 http://dx.doi.org/10.1016/j.xgen.2021.100088 |
| work_keys_str_mv | AT plagnolvincent polygenicscoredevelopmentintheeraoflargescalebiobanks |