A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer

Hirt et al.(1) report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid biobank also represents a valuable tool to uncover new dr...

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Detalles Bibliográficos
Autores principales: Mainardi, Sara, Bernards, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903715/
https://www.ncbi.nlm.nih.gov/pubmed/36778660
http://dx.doi.org/10.1016/j.xgen.2022.100100
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author Mainardi, Sara
Bernards, Rene
author_facet Mainardi, Sara
Bernards, Rene
author_sort Mainardi, Sara
collection PubMed
description Hirt et al.(1) report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid biobank also represents a valuable tool to uncover new drug-gene interactions in pancreatic tumors.
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spelling pubmed-99037152023-02-10 A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer Mainardi, Sara Bernards, Rene Cell Genom Preview Hirt et al.(1) report an automated, high-throughput drug screening platform for organoid cultures to enable repurposing of previously approved drugs for pancreatic cancers harboring specific genetic alterations. The pancreatic cancer organoid biobank also represents a valuable tool to uncover new drug-gene interactions in pancreatic tumors. Elsevier 2022-02-09 /pmc/articles/PMC9903715/ /pubmed/36778660 http://dx.doi.org/10.1016/j.xgen.2022.100100 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Mainardi, Sara
Bernards, Rene
A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title_full A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title_fullStr A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title_full_unstemmed A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title_short A large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
title_sort large-scale organoid-based screening platform to advance drug repurposing in pancreatic cancer
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903715/
https://www.ncbi.nlm.nih.gov/pubmed/36778660
http://dx.doi.org/10.1016/j.xgen.2022.100100
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