More of less: Novel multi-ome profiling of single human neurons

Epigenetic modifications to DNA and chromatin interact to influence gene expression and cellular phenotypes, but defining these omics layers in complex tissues is a daunting task. In this issue of Cell Genomics, Luo et al. describe a novel single-cell multi-omic method, simultaneously profiling tran...

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Detalles Bibliográficos
Autores principales: Che, Huiwen, Thienpont, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903744/
https://www.ncbi.nlm.nih.gov/pubmed/36777334
http://dx.doi.org/10.1016/j.xgen.2022.100110
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author Che, Huiwen
Thienpont, Bernard
author_facet Che, Huiwen
Thienpont, Bernard
author_sort Che, Huiwen
collection PubMed
description Epigenetic modifications to DNA and chromatin interact to influence gene expression and cellular phenotypes, but defining these omics layers in complex tissues is a daunting task. In this issue of Cell Genomics, Luo et al. describe a novel single-cell multi-omic method, simultaneously profiling transcriptome, DNA methylome, and chromatin accessibility, to shed light on human neurons.
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spelling pubmed-99037442023-02-10 More of less: Novel multi-ome profiling of single human neurons Che, Huiwen Thienpont, Bernard Cell Genom Preview Epigenetic modifications to DNA and chromatin interact to influence gene expression and cellular phenotypes, but defining these omics layers in complex tissues is a daunting task. In this issue of Cell Genomics, Luo et al. describe a novel single-cell multi-omic method, simultaneously profiling transcriptome, DNA methylome, and chromatin accessibility, to shed light on human neurons. Elsevier 2022-03-09 /pmc/articles/PMC9903744/ /pubmed/36777334 http://dx.doi.org/10.1016/j.xgen.2022.100110 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Preview
Che, Huiwen
Thienpont, Bernard
More of less: Novel multi-ome profiling of single human neurons
title More of less: Novel multi-ome profiling of single human neurons
title_full More of less: Novel multi-ome profiling of single human neurons
title_fullStr More of less: Novel multi-ome profiling of single human neurons
title_full_unstemmed More of less: Novel multi-ome profiling of single human neurons
title_short More of less: Novel multi-ome profiling of single human neurons
title_sort more of less: novel multi-ome profiling of single human neurons
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903744/
https://www.ncbi.nlm.nih.gov/pubmed/36777334
http://dx.doi.org/10.1016/j.xgen.2022.100110
work_keys_str_mv AT chehuiwen moreoflessnovelmultiomeprofilingofsinglehumanneurons
AT thienpontbernard moreoflessnovelmultiomeprofilingofsinglehumanneurons

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