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Global priorities for large-scale biomarker-based prospective cohorts
The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903754/ https://www.ncbi.nlm.nih.gov/pubmed/36778137 http://dx.doi.org/10.1016/j.xgen.2022.100141 |
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author | Collins, Rory Balaconis, Mary K. Brunak, Søren Chen, Zhengming De Silva, Mary Gaziano, J. Michael Ginsburg, Geoffrey S. Jha, Prabhat Kuri, Pablo Metspalu, Andres Mulder, Nicola Risch, Neil |
author_facet | Collins, Rory Balaconis, Mary K. Brunak, Søren Chen, Zhengming De Silva, Mary Gaziano, J. Michael Ginsburg, Geoffrey S. Jha, Prabhat Kuri, Pablo Metspalu, Andres Mulder, Nicola Risch, Neil |
author_sort | Collins, Rory |
collection | PubMed |
description | The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world. |
format | Online Article Text |
id | pubmed-9903754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99037542023-02-10 Global priorities for large-scale biomarker-based prospective cohorts Collins, Rory Balaconis, Mary K. Brunak, Søren Chen, Zhengming De Silva, Mary Gaziano, J. Michael Ginsburg, Geoffrey S. Jha, Prabhat Kuri, Pablo Metspalu, Andres Mulder, Nicola Risch, Neil Cell Genom Commentary The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world. Elsevier 2022-06-08 /pmc/articles/PMC9903754/ /pubmed/36778137 http://dx.doi.org/10.1016/j.xgen.2022.100141 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Collins, Rory Balaconis, Mary K. Brunak, Søren Chen, Zhengming De Silva, Mary Gaziano, J. Michael Ginsburg, Geoffrey S. Jha, Prabhat Kuri, Pablo Metspalu, Andres Mulder, Nicola Risch, Neil Global priorities for large-scale biomarker-based prospective cohorts |
title | Global priorities for large-scale biomarker-based prospective cohorts |
title_full | Global priorities for large-scale biomarker-based prospective cohorts |
title_fullStr | Global priorities for large-scale biomarker-based prospective cohorts |
title_full_unstemmed | Global priorities for large-scale biomarker-based prospective cohorts |
title_short | Global priorities for large-scale biomarker-based prospective cohorts |
title_sort | global priorities for large-scale biomarker-based prospective cohorts |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903754/ https://www.ncbi.nlm.nih.gov/pubmed/36778137 http://dx.doi.org/10.1016/j.xgen.2022.100141 |
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