Genetic perturbations go spatial

Tissue-tumor interactivity is the culmination of cell intrinsic features and their extrinsic interactions with the environment. Recently in Cell, Dhainaut and Rose et al. established a strategy to track pooled CRISPR-modified cells in vivo using protein barcodes (Pro-Codes) and measure their impact...

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Detalles Bibliográficos
Autores principales: Teng, Katie, Jackson, Hartland Warren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903767/
https://www.ncbi.nlm.nih.gov/pubmed/36776528
http://dx.doi.org/10.1016/j.xgen.2022.100120
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author Teng, Katie
Jackson, Hartland Warren
author_facet Teng, Katie
Jackson, Hartland Warren
author_sort Teng, Katie
collection PubMed
description Tissue-tumor interactivity is the culmination of cell intrinsic features and their extrinsic interactions with the environment. Recently in Cell, Dhainaut and Rose et al. established a strategy to track pooled CRISPR-modified cells in vivo using protein barcodes (Pro-Codes) and measure their impact on the tumor microenvironment through multiplexed imaging and spatial transcriptomics of intact tissues.(1)
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spelling pubmed-99037672023-02-10 Genetic perturbations go spatial Teng, Katie Jackson, Hartland Warren Cell Genom Preview Tissue-tumor interactivity is the culmination of cell intrinsic features and their extrinsic interactions with the environment. Recently in Cell, Dhainaut and Rose et al. established a strategy to track pooled CRISPR-modified cells in vivo using protein barcodes (Pro-Codes) and measure their impact on the tumor microenvironment through multiplexed imaging and spatial transcriptomics of intact tissues.(1) Elsevier 2022-04-13 /pmc/articles/PMC9903767/ /pubmed/36776528 http://dx.doi.org/10.1016/j.xgen.2022.100120 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Teng, Katie
Jackson, Hartland Warren
Genetic perturbations go spatial
title Genetic perturbations go spatial
title_full Genetic perturbations go spatial
title_fullStr Genetic perturbations go spatial
title_full_unstemmed Genetic perturbations go spatial
title_short Genetic perturbations go spatial
title_sort genetic perturbations go spatial
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903767/
https://www.ncbi.nlm.nih.gov/pubmed/36776528
http://dx.doi.org/10.1016/j.xgen.2022.100120
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