Multi-hallmark long noncoding RNA maps reveal non-small cell lung cancer vulnerabilities

Long noncoding RNAs (lncRNAs) are widely dysregulated in cancer, yet their functional roles in cancer hallmarks remain unclear. We employ pooled CRISPR deletion to perturb 831 lncRNAs detected in KRAS-mutant non-small cell lung cancer (NSCLC) and measure their contribution to proliferation, chemores...

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Detalles Bibliográficos
Autores principales: Esposito, Roberta, Polidori, Taisia, Meise, Dominik F., Pulido-Quetglas, Carlos, Chouvardas, Panagiotis, Forster, Stefan, Schaerer, Paulina, Kobel, Andrea, Schlatter, Juliette, Kerkhof, Erik, Roemmele, Michaela, Rice, Emily S., Zhu, Lina, Lanzós, Andrés, Guillen-Ramirez, Hugo A., Basile, Giulia, Carrozzo, Irene, Vancura, Adrienne, Ullrich, Sebastian, Andrades, Alvaro, Harvey, Dylan, Medina, Pedro P., Ma, Patrick C., Haefliger, Simon, Wang, Xin, Martinez, Ivan, Ochsenbein, Adrian F., Riether, Carsten, Johnson, Rory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903773/
https://www.ncbi.nlm.nih.gov/pubmed/36778670
http://dx.doi.org/10.1016/j.xgen.2022.100171

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