Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological co...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Namba, Shinichi, Lopera, Esteban, Kerminen, Sini, Tsuo, Kristin, Läll, Kristi, Kanai, Masahiro, Zhou, Wei, Wu, Kuan-Han, Favé, Marie-Julie, Bhatta, Laxmi, Awadalla, Philip, Brumpton, Ben, Deelen, Patrick, Hveem, Kristian, Lo Faro, Valeria, Mägi, Reedik, Murakami, Yoshinori, Sanna, Serena, Smoller, Jordan W., Uzunovic, Jasmina, Wolford, Brooke N., Willer, Cristen, Gamazon, Eric R., Cox, Nancy J., Surakka, Ida, Okada, Yukinori, Martin, Alicia R., Hirbo, Jibril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903818/
https://www.ncbi.nlm.nih.gov/pubmed/36777179
http://dx.doi.org/10.1016/j.xgen.2022.100241

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