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Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors

BACKGROUND: Disparities in the health and economic burden of gonorrhoea have not been systematically quantified. We estimated population-level health losses and costs associated with gonococcal infection and sequelae in the United States. METHODS: We used probability-tree models to capture gonorrhoe...

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Autores principales: Li, Yunfei, Rönn, Minttu M., Tuite, Ashleigh R., Chesson, Harrell W., Gift, Thomas L., Trikalinos, Thomas A., Testa, Christian, Bellerose, Meghan, Hsu, Katherine, Berruti, Andrés A., Malyuta, Yelena, Menzies, Nicolas A., Salomon, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904145/
https://www.ncbi.nlm.nih.gov/pubmed/36777156
http://dx.doi.org/10.1016/j.lana.2022.100364
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author Li, Yunfei
Rönn, Minttu M.
Tuite, Ashleigh R.
Chesson, Harrell W.
Gift, Thomas L.
Trikalinos, Thomas A.
Testa, Christian
Bellerose, Meghan
Hsu, Katherine
Berruti, Andrés A.
Malyuta, Yelena
Menzies, Nicolas A.
Salomon, Joshua A.
author_facet Li, Yunfei
Rönn, Minttu M.
Tuite, Ashleigh R.
Chesson, Harrell W.
Gift, Thomas L.
Trikalinos, Thomas A.
Testa, Christian
Bellerose, Meghan
Hsu, Katherine
Berruti, Andrés A.
Malyuta, Yelena
Menzies, Nicolas A.
Salomon, Joshua A.
author_sort Li, Yunfei
collection PubMed
description BACKGROUND: Disparities in the health and economic burden of gonorrhoea have not been systematically quantified. We estimated population-level health losses and costs associated with gonococcal infection and sequelae in the United States. METHODS: We used probability-tree models to capture gonorrhoea sequelae and to estimate attributable disease burden in terms of the discounted lifetime costs and quality-adjusted life-years (QALYs) lost due to incident infections acquired during 2015 from the healthcare system perspective. Numbers of infections in 2015 were obtained from a published gonorrhoea transmission model. We evaluated population-level disease burden, disaggregated by sex, age, race/ethnicity, and for men who have sex with men (MSM). We conducted a multivariate sensitivity analysis for key parameters. FINDINGS: Discounted lifetime QALYs lost per incident gonococcal infection were estimated as 0.093 (95% uncertainty interval [UI] 0.022-0.22) for women, 0.0020 (0.0015-0.0024) for heterosexual men, and 0.0015 (0.00070-0.0021) for MSM. Discounted lifetime costs per incident infection were USD 261 (109-480), 169 (88-263), and 133 (50-239), respectively. At the population level, total discounted lifetime QALYs lost due to infections acquired during 2015 were 53,293 (12,326-125,366) for women, 621 (430-872) for heterosexual men, and 1,078 (427-1,870) for MSM. Total discounted lifetime costs were USD 150 million (64-277 million), 54 million (25-92 million), and 97 million (34-197 million), respectively. The highest total burden of both QALYs and costs at the population-level was observed in Non-Hispanic Black women, and highest burden per 1,000 person-years was identified in MSM among men and American Indian/Alaska Native among women. INTERPRETATION: Gonorrhoea causes substantial health losses and costs in the United States. These results can inform planning and prioritization of prevention services. FUNDING: Centers for Disease Control and Prevention, Charles A. King Trust.
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spelling pubmed-99041452023-02-10 Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors Li, Yunfei Rönn, Minttu M. Tuite, Ashleigh R. Chesson, Harrell W. Gift, Thomas L. Trikalinos, Thomas A. Testa, Christian Bellerose, Meghan Hsu, Katherine Berruti, Andrés A. Malyuta, Yelena Menzies, Nicolas A. Salomon, Joshua A. Lancet Reg Health Am Articles BACKGROUND: Disparities in the health and economic burden of gonorrhoea have not been systematically quantified. We estimated population-level health losses and costs associated with gonococcal infection and sequelae in the United States. METHODS: We used probability-tree models to capture gonorrhoea sequelae and to estimate attributable disease burden in terms of the discounted lifetime costs and quality-adjusted life-years (QALYs) lost due to incident infections acquired during 2015 from the healthcare system perspective. Numbers of infections in 2015 were obtained from a published gonorrhoea transmission model. We evaluated population-level disease burden, disaggregated by sex, age, race/ethnicity, and for men who have sex with men (MSM). We conducted a multivariate sensitivity analysis for key parameters. FINDINGS: Discounted lifetime QALYs lost per incident gonococcal infection were estimated as 0.093 (95% uncertainty interval [UI] 0.022-0.22) for women, 0.0020 (0.0015-0.0024) for heterosexual men, and 0.0015 (0.00070-0.0021) for MSM. Discounted lifetime costs per incident infection were USD 261 (109-480), 169 (88-263), and 133 (50-239), respectively. At the population level, total discounted lifetime QALYs lost due to infections acquired during 2015 were 53,293 (12,326-125,366) for women, 621 (430-872) for heterosexual men, and 1,078 (427-1,870) for MSM. Total discounted lifetime costs were USD 150 million (64-277 million), 54 million (25-92 million), and 97 million (34-197 million), respectively. The highest total burden of both QALYs and costs at the population-level was observed in Non-Hispanic Black women, and highest burden per 1,000 person-years was identified in MSM among men and American Indian/Alaska Native among women. INTERPRETATION: Gonorrhoea causes substantial health losses and costs in the United States. These results can inform planning and prioritization of prevention services. FUNDING: Centers for Disease Control and Prevention, Charles A. King Trust. Elsevier 2022-09-05 /pmc/articles/PMC9904145/ /pubmed/36777156 http://dx.doi.org/10.1016/j.lana.2022.100364 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles
Li, Yunfei
Rönn, Minttu M.
Tuite, Ashleigh R.
Chesson, Harrell W.
Gift, Thomas L.
Trikalinos, Thomas A.
Testa, Christian
Bellerose, Meghan
Hsu, Katherine
Berruti, Andrés A.
Malyuta, Yelena
Menzies, Nicolas A.
Salomon, Joshua A.
Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title_full Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title_fullStr Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title_full_unstemmed Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title_short Estimated costs and quality-adjusted life-years lost due to N. gonorrhoeae infections acquired in 2015 in the United States: A modelling study of overall burden and disparities by age, race/ethnicity, and other factors
title_sort estimated costs and quality-adjusted life-years lost due to n. gonorrhoeae infections acquired in 2015 in the united states: a modelling study of overall burden and disparities by age, race/ethnicity, and other factors
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904145/
https://www.ncbi.nlm.nih.gov/pubmed/36777156
http://dx.doi.org/10.1016/j.lana.2022.100364
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