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tRNA derived fragments:A novel player in gene regulation and applications in cancer

The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation, has been demonstrated. In this review, we brie...

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Autores principales: Zhang, Shuangshuang, Yu, Xiuchong, Xie, Yaoyao, Ye, Guoliang, Guo, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904238/
https://www.ncbi.nlm.nih.gov/pubmed/36761955
http://dx.doi.org/10.3389/fonc.2023.1063930
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author Zhang, Shuangshuang
Yu, Xiuchong
Xie, Yaoyao
Ye, Guoliang
Guo, Junming
author_facet Zhang, Shuangshuang
Yu, Xiuchong
Xie, Yaoyao
Ye, Guoliang
Guo, Junming
author_sort Zhang, Shuangshuang
collection PubMed
description The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation, has been demonstrated. In this review, we briefly summarize the current literatures on the classification of tRFs and the effects of tRNA modification on tRF biogenesis. Moreover, we highlight the tRF repertoire of biological roles such as gene silencing, and regulation of translation, cell apoptosis, and epigenetics. We also summarize the biological roles of various tRFs in cancer development and viral infection, their potential value as diagnostic and prognostic biomarkers for different types of cancers, and their potential use in cancer therapy.
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spelling pubmed-99042382023-02-08 tRNA derived fragments:A novel player in gene regulation and applications in cancer Zhang, Shuangshuang Yu, Xiuchong Xie, Yaoyao Ye, Guoliang Guo, Junming Front Oncol Oncology The heterogeneous species of tRNA-derived fragments (tRFs) with specific biological functions was recently identified. Distinct roles of tRFs in tumor development and viral infection, mediated through transcriptional and post-transcriptional regulation, has been demonstrated. In this review, we briefly summarize the current literatures on the classification of tRFs and the effects of tRNA modification on tRF biogenesis. Moreover, we highlight the tRF repertoire of biological roles such as gene silencing, and regulation of translation, cell apoptosis, and epigenetics. We also summarize the biological roles of various tRFs in cancer development and viral infection, their potential value as diagnostic and prognostic biomarkers for different types of cancers, and their potential use in cancer therapy. Frontiers Media S.A. 2023-01-20 /pmc/articles/PMC9904238/ /pubmed/36761955 http://dx.doi.org/10.3389/fonc.2023.1063930 Text en Copyright © 2023 Zhang, Yu, Xie, Ye and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Shuangshuang
Yu, Xiuchong
Xie, Yaoyao
Ye, Guoliang
Guo, Junming
tRNA derived fragments:A novel player in gene regulation and applications in cancer
title tRNA derived fragments:A novel player in gene regulation and applications in cancer
title_full tRNA derived fragments:A novel player in gene regulation and applications in cancer
title_fullStr tRNA derived fragments:A novel player in gene regulation and applications in cancer
title_full_unstemmed tRNA derived fragments:A novel player in gene regulation and applications in cancer
title_short tRNA derived fragments:A novel player in gene regulation and applications in cancer
title_sort trna derived fragments:a novel player in gene regulation and applications in cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904238/
https://www.ncbi.nlm.nih.gov/pubmed/36761955
http://dx.doi.org/10.3389/fonc.2023.1063930
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