The biology of TREM receptors

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atheroscle...

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Detalles Bibliográficos
Autor principal: Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904274/
https://www.ncbi.nlm.nih.gov/pubmed/36750615
http://dx.doi.org/10.1038/s41577-023-00837-1
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author Colonna, Marco
author_facet Colonna, Marco
author_sort Colonna, Marco
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description Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.
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spelling pubmed-99042742023-02-07 The biology of TREM receptors Colonna, Marco Nat Rev Immunol Review Article Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology. Nature Publishing Group UK 2023-02-07 /pmc/articles/PMC9904274/ /pubmed/36750615 http://dx.doi.org/10.1038/s41577-023-00837-1 Text en © Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Colonna, Marco
The biology of TREM receptors
title The biology of TREM receptors
title_full The biology of TREM receptors
title_fullStr The biology of TREM receptors
title_full_unstemmed The biology of TREM receptors
title_short The biology of TREM receptors
title_sort biology of trem receptors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904274/
https://www.ncbi.nlm.nih.gov/pubmed/36750615
http://dx.doi.org/10.1038/s41577-023-00837-1
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