Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles

An unprecedented metal-free regioselective halogenation of 2H-indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazol...

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Autores principales: Zhang, Changjun, Wei, Tingting, Yu, Zhichen, Ding, Yuxin, Su, Weike, Xie, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904359/
https://www.ncbi.nlm.nih.gov/pubmed/36762091
http://dx.doi.org/10.1039/d2ra07398f
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author Zhang, Changjun
Wei, Tingting
Yu, Zhichen
Ding, Yuxin
Su, Weike
Xie, Yuanyuan
author_facet Zhang, Changjun
Wei, Tingting
Yu, Zhichen
Ding, Yuxin
Su, Weike
Xie, Yuanyuan
author_sort Zhang, Changjun
collection PubMed
description An unprecedented metal-free regioselective halogenation of 2H-indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Notably, this approach features environmentally friendly solvents, mild reaction conditions, simple execution and short reaction time.
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spelling pubmed-99043592023-02-08 Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles Zhang, Changjun Wei, Tingting Yu, Zhichen Ding, Yuxin Su, Weike Xie, Yuanyuan RSC Adv Chemistry An unprecedented metal-free regioselective halogenation of 2H-indazoles has been revealed, which not only realized the highly selective synthesis of mono-halogenated products, but also completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Notably, this approach features environmentally friendly solvents, mild reaction conditions, simple execution and short reaction time. The Royal Society of Chemistry 2023-02-07 /pmc/articles/PMC9904359/ /pubmed/36762091 http://dx.doi.org/10.1039/d2ra07398f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhang, Changjun
Wei, Tingting
Yu, Zhichen
Ding, Yuxin
Su, Weike
Xie, Yuanyuan
Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title_full Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title_fullStr Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title_full_unstemmed Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title_short Metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
title_sort metal-free regioselective mono- and poly-halogenation of 2-substituted indazoles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904359/
https://www.ncbi.nlm.nih.gov/pubmed/36762091
http://dx.doi.org/10.1039/d2ra07398f
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