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Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China
BACKGROUND: To investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs. METHODS: Retrospective analysis of the pathogenic bacterium distrib...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904418/ https://www.ncbi.nlm.nih.gov/pubmed/36761201 http://dx.doi.org/10.3389/fendo.2023.1113622 |
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author | Liu, Wei Song, Liying Sun, Wei Fang, Weijin Wang, Chunjiang |
author_facet | Liu, Wei Song, Liying Sun, Wei Fang, Weijin Wang, Chunjiang |
author_sort | Liu, Wei |
collection | PubMed |
description | BACKGROUND: To investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs. METHODS: Retrospective analysis of the pathogenic bacterium distribution and antimicrobial susceptibility isolated from 581 DFI patients with different Wagner grades. RESULTS: The 534 positive samples included 473 cases (88.58%)) of monomicrobial infections and 61 cases (11.42%) of polymicrobial infections before antibiotic therapy. A total of 656 strains were cultivated, including 387 (58.99%) strains of gram-positive organisms (GPOs), 235 (35.82%) gram-negative bacilli (GNB), and 21 (3.20%) fungal strains. Polymicrobial infections mainly occurred in patients with Wagner grade 3-4 ulcers. GPOs were predominant in Wagner grades 1-3 (grade 1: 96.67%, grade 2: 76.52%, grade 3 62.81%), and the most common was Staphylococcus aureus (grade 1: 31.66%, grade 2: 33.04%, grade 3 35.53%). GNB were predominant in grades 4-5 (grade 4: 51.46%, grade 5:60%), and the most common GNB in Wagner grades 4-5 was Proteus (grade 4:27.88%, grade 5: 42.86%), while the most common GPO was Enterococcus (grade 4:34.48%, grade 5:25.00%). Staphylococcus (including MRSA) and Enterococcus were still highly sensitive to vancomycin, linezolid, and tigecycline. Most GNB were still highly sensitive to meropenem, tigecycline, ertapenem, and amikacin. Proteus was most sensitive to amikacin (97.14%), followed by meropenem (92%) and ertapenem (80%). CONCLUSION: The distribution of microbes and antimicrobial susceptibility in DFI patients varied with different Wagner grades. The most appropriate antimicrobial therapy should be selected based on the pathogen culture and antimicrobial susceptibility. |
format | Online Article Text |
id | pubmed-9904418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99044182023-02-08 Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China Liu, Wei Song, Liying Sun, Wei Fang, Weijin Wang, Chunjiang Front Endocrinol (Lausanne) Endocrinology BACKGROUND: To investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs. METHODS: Retrospective analysis of the pathogenic bacterium distribution and antimicrobial susceptibility isolated from 581 DFI patients with different Wagner grades. RESULTS: The 534 positive samples included 473 cases (88.58%)) of monomicrobial infections and 61 cases (11.42%) of polymicrobial infections before antibiotic therapy. A total of 656 strains were cultivated, including 387 (58.99%) strains of gram-positive organisms (GPOs), 235 (35.82%) gram-negative bacilli (GNB), and 21 (3.20%) fungal strains. Polymicrobial infections mainly occurred in patients with Wagner grade 3-4 ulcers. GPOs were predominant in Wagner grades 1-3 (grade 1: 96.67%, grade 2: 76.52%, grade 3 62.81%), and the most common was Staphylococcus aureus (grade 1: 31.66%, grade 2: 33.04%, grade 3 35.53%). GNB were predominant in grades 4-5 (grade 4: 51.46%, grade 5:60%), and the most common GNB in Wagner grades 4-5 was Proteus (grade 4:27.88%, grade 5: 42.86%), while the most common GPO was Enterococcus (grade 4:34.48%, grade 5:25.00%). Staphylococcus (including MRSA) and Enterococcus were still highly sensitive to vancomycin, linezolid, and tigecycline. Most GNB were still highly sensitive to meropenem, tigecycline, ertapenem, and amikacin. Proteus was most sensitive to amikacin (97.14%), followed by meropenem (92%) and ertapenem (80%). CONCLUSION: The distribution of microbes and antimicrobial susceptibility in DFI patients varied with different Wagner grades. The most appropriate antimicrobial therapy should be selected based on the pathogen culture and antimicrobial susceptibility. Frontiers Media S.A. 2023-01-24 /pmc/articles/PMC9904418/ /pubmed/36761201 http://dx.doi.org/10.3389/fendo.2023.1113622 Text en Copyright © 2023 Liu, Song, Sun, Fang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Liu, Wei Song, Liying Sun, Wei Fang, Weijin Wang, Chunjiang Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title | Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title_full | Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title_fullStr | Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title_full_unstemmed | Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title_short | Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South China |
title_sort | distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in south china |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904418/ https://www.ncbi.nlm.nih.gov/pubmed/36761201 http://dx.doi.org/10.3389/fendo.2023.1113622 |
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