Pretreatment with antibiotics is associated with reduced therapeutic response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma

AIM: Alterations in microbial composition of gut microbiota due to antibiotics (ATB) may lead to resistance to immune checkpoint inhibitors (ICIs). This study aimed to assess the impact of ATB use on therapeutic response in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bev...

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Detalles Bibliográficos
Autores principales: Maesaka, Kazuki, Sakamori, Ryotaro, Yamada, Ryoko, Doi, Akira, Tahata, Yuki, Ohkawa, Kazuyoshi, Oshita, Masahide, Miyazaki, Masanori, Yakushijin, Takayuki, Nozaki, Yasutoshi, Matsumoto, Kengo, Tanaka, Satoshi, Kaneko, Akira, Iio, Sadaharu, Nawa, Takatoshi, Yamada, Yukinori, Morishita, Naoki, Usui, Takeo, Hiramatsu, Naoki, Doi, Yoshinori, Sakakibara, Mitsuru, Imanaka, Kazuho, Yoshida, Yuichi, Kodama, Takahiro, Hikita, Hayato, Tatsumi, Tomohide, Takehara, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904470/
https://www.ncbi.nlm.nih.gov/pubmed/36749777
http://dx.doi.org/10.1371/journal.pone.0281459

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