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Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures

The spread of seizures across brain networks is the main impairing factor, often leading to loss-of-consciousness, in people with epilepsy. Despite advances in recording and modeling brain activity, uncovering the nature of seizure spreading dynamics remains an important challenge to understanding a...

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Autores principales: Moosavi, S Amin, Truccolo, Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904505/
https://www.ncbi.nlm.nih.gov/pubmed/36749796
http://dx.doi.org/10.1371/journal.pcbi.1010852
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author Moosavi, S Amin
Truccolo, Wilson
author_facet Moosavi, S Amin
Truccolo, Wilson
author_sort Moosavi, S Amin
collection PubMed
description The spread of seizures across brain networks is the main impairing factor, often leading to loss-of-consciousness, in people with epilepsy. Despite advances in recording and modeling brain activity, uncovering the nature of seizure spreading dynamics remains an important challenge to understanding and treating pharmacologically resistant epilepsy. To address this challenge, we introduce a new probabilistic model that captures the spreading dynamics in patient-specific complex networks. Network connectivity and interaction time delays between brain areas were estimated from white-matter tractography. The model’s computational tractability allows it to play an important complementary role to more detailed models of seizure dynamics. We illustrate model fitting and predictive performance in the context of patient-specific Epileptor networks. We derive the phase diagram of spread size (order parameter) as a function of brain excitability and global connectivity strength, for different patient-specific networks. Phase diagrams allow the prediction of whether a seizure will spread depending on excitability and connectivity strength. In addition, model simulations predict the temporal order of seizure spread across network nodes. Furthermore, we show that the order parameter can exhibit both discontinuous and continuous (critical) phase transitions as neural excitability and connectivity strength are varied. Existence of a critical point, where response functions and fluctuations in spread size show power-law divergence with respect to control parameters, is supported by mean-field approximations and finite-size scaling analyses. Notably, the critical point separates two distinct regimes of spreading dynamics characterized by unimodal and bimodal spread-size distributions. Our study sheds new light on the nature of phase transitions and fluctuations in seizure spreading dynamics. We expect it to play an important role in the development of closed-loop stimulation approaches for preventing seizure spread in pharmacologically resistant epilepsy. Our findings may also be of interest to related models of spreading dynamics in epidemiology, biology, finance, and statistical physics.
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spelling pubmed-99045052023-02-08 Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures Moosavi, S Amin Truccolo, Wilson PLoS Comput Biol Research Article The spread of seizures across brain networks is the main impairing factor, often leading to loss-of-consciousness, in people with epilepsy. Despite advances in recording and modeling brain activity, uncovering the nature of seizure spreading dynamics remains an important challenge to understanding and treating pharmacologically resistant epilepsy. To address this challenge, we introduce a new probabilistic model that captures the spreading dynamics in patient-specific complex networks. Network connectivity and interaction time delays between brain areas were estimated from white-matter tractography. The model’s computational tractability allows it to play an important complementary role to more detailed models of seizure dynamics. We illustrate model fitting and predictive performance in the context of patient-specific Epileptor networks. We derive the phase diagram of spread size (order parameter) as a function of brain excitability and global connectivity strength, for different patient-specific networks. Phase diagrams allow the prediction of whether a seizure will spread depending on excitability and connectivity strength. In addition, model simulations predict the temporal order of seizure spread across network nodes. Furthermore, we show that the order parameter can exhibit both discontinuous and continuous (critical) phase transitions as neural excitability and connectivity strength are varied. Existence of a critical point, where response functions and fluctuations in spread size show power-law divergence with respect to control parameters, is supported by mean-field approximations and finite-size scaling analyses. Notably, the critical point separates two distinct regimes of spreading dynamics characterized by unimodal and bimodal spread-size distributions. Our study sheds new light on the nature of phase transitions and fluctuations in seizure spreading dynamics. We expect it to play an important role in the development of closed-loop stimulation approaches for preventing seizure spread in pharmacologically resistant epilepsy. Our findings may also be of interest to related models of spreading dynamics in epidemiology, biology, finance, and statistical physics. Public Library of Science 2023-02-07 /pmc/articles/PMC9904505/ /pubmed/36749796 http://dx.doi.org/10.1371/journal.pcbi.1010852 Text en © 2023 Moosavi, Truccolo https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Moosavi, S Amin
Truccolo, Wilson
Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title_full Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title_fullStr Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title_full_unstemmed Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title_short Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures
title_sort criticality in probabilistic models of spreading dynamics in brain networks: epileptic seizures
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904505/
https://www.ncbi.nlm.nih.gov/pubmed/36749796
http://dx.doi.org/10.1371/journal.pcbi.1010852
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