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Lifespan extension in female mice by early, transient exposure to adult female olfactory cues

Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life gr...

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Autores principales: Garratt, Michael, Erturk, Ilkim, Alonzo, Roxann, Zufall, Frank, Leinders-Zufall, Trese, Pletcher, Scott D, Miller, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904757/
https://www.ncbi.nlm.nih.gov/pubmed/36525360
http://dx.doi.org/10.7554/eLife.84060
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author Garratt, Michael
Erturk, Ilkim
Alonzo, Roxann
Zufall, Frank
Leinders-Zufall, Trese
Pletcher, Scott D
Miller, Richard A
author_facet Garratt, Michael
Erturk, Ilkim
Alonzo, Roxann
Zufall, Frank
Leinders-Zufall, Trese
Pletcher, Scott D
Miller, Richard A
author_sort Garratt, Michael
collection PubMed
description Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life growth rate. The pace of early development in mice can also be influenced by exposure of nursing and weanling mice to olfactory cues. In particular, odors of same-sex adult mice can in some circumstances delay maturation. We hypothesized that olfactory information might also have a sex-specific effect on lifespan, and we show here that the lifespan of female mice can be increased significantly by odors from adult females administered transiently, that is from 3 days until 60 days of age. Female lifespan was not modified by male odors, nor was male lifespan susceptible to odors from adults of either sex. Conditional deletion of the G protein Gαo in the olfactory system, which leads to impaired accessory olfactory system function and blunted reproductive priming responses to male odors in females, did not modify the effect of female odors on female lifespan. Our data provide support for the idea that very young mice are susceptible to influences that can have long-lasting effects on health maintenance in later life, and provide a potential example of lifespan extension by olfactory cues in mice.
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spelling pubmed-99047572023-02-08 Lifespan extension in female mice by early, transient exposure to adult female olfactory cues Garratt, Michael Erturk, Ilkim Alonzo, Roxann Zufall, Frank Leinders-Zufall, Trese Pletcher, Scott D Miller, Richard A eLife Cell Biology Several previous lines of research have suggested, indirectly, that mouse lifespan is particularly susceptible to endocrine or nutritional signals in the first few weeks of life, as tested by manipulations of litter size, growth hormone levels, or mutations with effects specifically on early-life growth rate. The pace of early development in mice can also be influenced by exposure of nursing and weanling mice to olfactory cues. In particular, odors of same-sex adult mice can in some circumstances delay maturation. We hypothesized that olfactory information might also have a sex-specific effect on lifespan, and we show here that the lifespan of female mice can be increased significantly by odors from adult females administered transiently, that is from 3 days until 60 days of age. Female lifespan was not modified by male odors, nor was male lifespan susceptible to odors from adults of either sex. Conditional deletion of the G protein Gαo in the olfactory system, which leads to impaired accessory olfactory system function and blunted reproductive priming responses to male odors in females, did not modify the effect of female odors on female lifespan. Our data provide support for the idea that very young mice are susceptible to influences that can have long-lasting effects on health maintenance in later life, and provide a potential example of lifespan extension by olfactory cues in mice. eLife Sciences Publications, Ltd 2022-12-16 /pmc/articles/PMC9904757/ /pubmed/36525360 http://dx.doi.org/10.7554/eLife.84060 Text en © 2022, Garratt et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Garratt, Michael
Erturk, Ilkim
Alonzo, Roxann
Zufall, Frank
Leinders-Zufall, Trese
Pletcher, Scott D
Miller, Richard A
Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title_full Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title_fullStr Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title_full_unstemmed Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title_short Lifespan extension in female mice by early, transient exposure to adult female olfactory cues
title_sort lifespan extension in female mice by early, transient exposure to adult female olfactory cues
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904757/
https://www.ncbi.nlm.nih.gov/pubmed/36525360
http://dx.doi.org/10.7554/eLife.84060
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