Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. In this study, we used single-cel...

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Detalles Bibliográficos
Autores principales: Ainciburu, Marina, Ezponda, Teresa, Berastegui, Nerea, Alfonso-Pierola, Ana, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Alignani, Diego, Lamo-Espinosa, Jose, San-Julian, Mikel, Jiménez-Solas, Tamara, Lopez, Felix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Julia, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Lasaga, Miren, Gomez-Cabrero, David, Diez-Campelo, Maria, Valcarcel, David, Hernaez, Mikel, Romero, Juan P, Prosper, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904760/
https://www.ncbi.nlm.nih.gov/pubmed/36629404
http://dx.doi.org/10.7554/eLife.79363

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