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Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression

Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological func...

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Detalles Bibliográficos
Autores principales: Guo, Kai, Fang, Lingling, Li, Mingjian, Li, Aizheng, Liu, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904930/
https://www.ncbi.nlm.nih.gov/pubmed/36762036
http://dx.doi.org/10.1155/2023/4190849
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author Guo, Kai
Fang, Lingling
Li, Mingjian
Li, Aizheng
Liu, Na
author_facet Guo, Kai
Fang, Lingling
Li, Mingjian
Li, Aizheng
Liu, Na
author_sort Guo, Kai
collection PubMed
description Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505. Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505.
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spelling pubmed-99049302023-02-08 Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression Guo, Kai Fang, Lingling Li, Mingjian Li, Aizheng Liu, Na Behav Neurol Research Article Glioblastoma (GBM) is a highly malignant cancer, the prognosis of which is pretty poor. Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs, which play important roles in carcinogenesis process of many cancers including GBM. In this study, we want to clarify the expression, biological function, and molecular mechanism of lncRNA KTN1 antisense RNA 1 (KTN1-AS1) in GBM tumor progression. We found that KTN1-AS1 expression was upregulated in GBM tissues and cell lines. KTN1-AS1 played oncogenic roles to facilitate proliferation, migration, and invasion of GBM cells. Then, we revealed that miR-505 was a target of KTN1-AS1, and its expression was decreased in GBM. KTN1-AS1 contributed to GBM progression by mediating miR-505. Finally, we demonstrated that KTN1-AS1 upregulated some target oncogenes of miR-505 including ZEB2, HMGB1, and RUNX2 in GBM cells. All in all, we concluded that the highly expressed KTN1-AS1 in GBM played oncogenic roles to facilitate GBM progression by targeting miR-505. Hindawi 2023-01-31 /pmc/articles/PMC9904930/ /pubmed/36762036 http://dx.doi.org/10.1155/2023/4190849 Text en Copyright © 2023 Kai Guo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guo, Kai
Fang, Lingling
Li, Mingjian
Li, Aizheng
Liu, Na
Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title_full Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title_fullStr Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title_full_unstemmed Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title_short Long Non-coding RNA KTN1-AS1 Targets miR-505 to Promote Glioblastoma Progression
title_sort long non-coding rna ktn1-as1 targets mir-505 to promote glioblastoma progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904930/
https://www.ncbi.nlm.nih.gov/pubmed/36762036
http://dx.doi.org/10.1155/2023/4190849
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