p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression

The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes encoding enzymes for peroxisomal fatty acid β-oxidation (FAO). This leads to increased cytoso...

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Detalles Bibliográficos
Autores principales: Zhao, Jianhong, Zhou, Xiaojun, Chen, Baoxiang, Lu, Mingzhu, Wang, Genxin, Elumalai, Nagarajan, Tian, Chenhui, Zhang, Jinmiao, Liu, Yanliang, Chen, Zhiqiang, Zhou, Xinyi, Wu, Mingzhi, Li, Mengjiao, Prochownik, Edward V., Tavassoli, Ali, Jiang, Congqing, Li, Youjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905075/
https://www.ncbi.nlm.nih.gov/pubmed/36750554
http://dx.doi.org/10.1038/s41419-023-05625-2

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