Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes

Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammatory and antitumor effects. Although one pharmacokinetic study found that the metabolic parameters of the isomers were differ...

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Detalles Bibliográficos
Autores principales: Li, Yingzi, Liu, Xiaoyan, Li, Ludi, Zhang, Tao, Gao, Yadong, Zeng, Kewu, Wang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905117/
https://www.ncbi.nlm.nih.gov/pubmed/36762117
http://dx.doi.org/10.3389/fphar.2023.1093696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905117/
https://www.ncbi.nlm.nih.gov/pubmed/36762117
http://dx.doi.org/10.3389/fphar.2023.1093696

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