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Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study

BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of...

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Autores principales: Wood, Gregory, Johnsen, Pia Hedegaard, Pedersen, Anders Lehmann Dahl, Frederiksen, Christian Alcaraz, Poulsen, Steen Hvitfeldt, Bøtker, Hans Erik, Kim, Won Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905230/
https://www.ncbi.nlm.nih.gov/pubmed/36762305
http://dx.doi.org/10.3389/fcvm.2022.1054142
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author Wood, Gregory
Johnsen, Pia Hedegaard
Pedersen, Anders Lehmann Dahl
Frederiksen, Christian Alcaraz
Poulsen, Steen Hvitfeldt
Bøtker, Hans Erik
Kim, Won Yong
author_facet Wood, Gregory
Johnsen, Pia Hedegaard
Pedersen, Anders Lehmann Dahl
Frederiksen, Christian Alcaraz
Poulsen, Steen Hvitfeldt
Bøtker, Hans Erik
Kim, Won Yong
author_sort Wood, Gregory
collection PubMed
description BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. OBJECTIVE: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. METHODS: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. RESULTS: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). CONCLUSION: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.
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spelling pubmed-99052302023-02-08 Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study Wood, Gregory Johnsen, Pia Hedegaard Pedersen, Anders Lehmann Dahl Frederiksen, Christian Alcaraz Poulsen, Steen Hvitfeldt Bøtker, Hans Erik Kim, Won Yong Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. OBJECTIVE: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. METHODS: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. RESULTS: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). CONCLUSION: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone. Frontiers Media S.A. 2023-01-25 /pmc/articles/PMC9905230/ /pubmed/36762305 http://dx.doi.org/10.3389/fcvm.2022.1054142 Text en Copyright © 2023 Wood, Johnsen, Pedersen, Frederiksen, Poulsen, Bøtker and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wood, Gregory
Johnsen, Pia Hedegaard
Pedersen, Anders Lehmann Dahl
Frederiksen, Christian Alcaraz
Poulsen, Steen Hvitfeldt
Bøtker, Hans Erik
Kim, Won Yong
Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title_full Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title_fullStr Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title_full_unstemmed Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title_short Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
title_sort effect of remote ischaemic conditioning on left ventricular function in st-segment elevation myocardial infarction patients: the condi-2 echocardiographic sub-study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905230/
https://www.ncbi.nlm.nih.gov/pubmed/36762305
http://dx.doi.org/10.3389/fcvm.2022.1054142
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