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Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study
BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905230/ https://www.ncbi.nlm.nih.gov/pubmed/36762305 http://dx.doi.org/10.3389/fcvm.2022.1054142 |
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author | Wood, Gregory Johnsen, Pia Hedegaard Pedersen, Anders Lehmann Dahl Frederiksen, Christian Alcaraz Poulsen, Steen Hvitfeldt Bøtker, Hans Erik Kim, Won Yong |
author_facet | Wood, Gregory Johnsen, Pia Hedegaard Pedersen, Anders Lehmann Dahl Frederiksen, Christian Alcaraz Poulsen, Steen Hvitfeldt Bøtker, Hans Erik Kim, Won Yong |
author_sort | Wood, Gregory |
collection | PubMed |
description | BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. OBJECTIVE: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. METHODS: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. RESULTS: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). CONCLUSION: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone. |
format | Online Article Text |
id | pubmed-9905230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99052302023-02-08 Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study Wood, Gregory Johnsen, Pia Hedegaard Pedersen, Anders Lehmann Dahl Frederiksen, Christian Alcaraz Poulsen, Steen Hvitfeldt Bøtker, Hans Erik Kim, Won Yong Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. OBJECTIVE: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. METHODS: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. RESULTS: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). CONCLUSION: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone. Frontiers Media S.A. 2023-01-25 /pmc/articles/PMC9905230/ /pubmed/36762305 http://dx.doi.org/10.3389/fcvm.2022.1054142 Text en Copyright © 2023 Wood, Johnsen, Pedersen, Frederiksen, Poulsen, Bøtker and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Wood, Gregory Johnsen, Pia Hedegaard Pedersen, Anders Lehmann Dahl Frederiksen, Christian Alcaraz Poulsen, Steen Hvitfeldt Bøtker, Hans Erik Kim, Won Yong Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title | Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title_full | Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title_fullStr | Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title_full_unstemmed | Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title_short | Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study |
title_sort | effect of remote ischaemic conditioning on left ventricular function in st-segment elevation myocardial infarction patients: the condi-2 echocardiographic sub-study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905230/ https://www.ncbi.nlm.nih.gov/pubmed/36762305 http://dx.doi.org/10.3389/fcvm.2022.1054142 |
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