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Neural Correlates of Spatial Navigation in Primate Hippocampus
The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hip...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Nature Singapore
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905402/ https://www.ncbi.nlm.nih.gov/pubmed/36319893 http://dx.doi.org/10.1007/s12264-022-00968-w |
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author | Mao, Dun |
author_facet | Mao, Dun |
author_sort | Mao, Dun |
collection | PubMed |
description | The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks. |
format | Online Article Text |
id | pubmed-9905402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-99054022023-02-08 Neural Correlates of Spatial Navigation in Primate Hippocampus Mao, Dun Neurosci Bull Review The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks. Springer Nature Singapore 2022-11-02 /pmc/articles/PMC9905402/ /pubmed/36319893 http://dx.doi.org/10.1007/s12264-022-00968-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Mao, Dun Neural Correlates of Spatial Navigation in Primate Hippocampus |
title | Neural Correlates of Spatial Navigation in Primate Hippocampus |
title_full | Neural Correlates of Spatial Navigation in Primate Hippocampus |
title_fullStr | Neural Correlates of Spatial Navigation in Primate Hippocampus |
title_full_unstemmed | Neural Correlates of Spatial Navigation in Primate Hippocampus |
title_short | Neural Correlates of Spatial Navigation in Primate Hippocampus |
title_sort | neural correlates of spatial navigation in primate hippocampus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905402/ https://www.ncbi.nlm.nih.gov/pubmed/36319893 http://dx.doi.org/10.1007/s12264-022-00968-w |
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