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Neural Correlates of Spatial Navigation in Primate Hippocampus

The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hip...

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Autor principal: Mao, Dun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905402/
https://www.ncbi.nlm.nih.gov/pubmed/36319893
http://dx.doi.org/10.1007/s12264-022-00968-w
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author Mao, Dun
author_facet Mao, Dun
author_sort Mao, Dun
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description The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks.
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spelling pubmed-99054022023-02-08 Neural Correlates of Spatial Navigation in Primate Hippocampus Mao, Dun Neurosci Bull Review The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks. Springer Nature Singapore 2022-11-02 /pmc/articles/PMC9905402/ /pubmed/36319893 http://dx.doi.org/10.1007/s12264-022-00968-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Mao, Dun
Neural Correlates of Spatial Navigation in Primate Hippocampus
title Neural Correlates of Spatial Navigation in Primate Hippocampus
title_full Neural Correlates of Spatial Navigation in Primate Hippocampus
title_fullStr Neural Correlates of Spatial Navigation in Primate Hippocampus
title_full_unstemmed Neural Correlates of Spatial Navigation in Primate Hippocampus
title_short Neural Correlates of Spatial Navigation in Primate Hippocampus
title_sort neural correlates of spatial navigation in primate hippocampus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905402/
https://www.ncbi.nlm.nih.gov/pubmed/36319893
http://dx.doi.org/10.1007/s12264-022-00968-w
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