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Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions
Aging is a major risk factor for many human diseases, including cognitive impairment, which affects a large population of the elderly. In the past few decades, our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expande...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905409/ https://www.ncbi.nlm.nih.gov/pubmed/36437436 http://dx.doi.org/10.1007/s12264-022-00969-9 |
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author | Jin, Menglong Cai, Shi-Qing |
author_facet | Jin, Menglong Cai, Shi-Qing |
author_sort | Jin, Menglong |
collection | PubMed |
description | Aging is a major risk factor for many human diseases, including cognitive impairment, which affects a large population of the elderly. In the past few decades, our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly, shedding light on the potential role of these changes in cognitive impairment. In this article, we review recent advances in understanding of the mechanisms underlying brain aging under normal and pathological conditions, compare their similarities and differences, discuss the causative and adaptive mechanisms of brain aging, and finally attempt to find some rules to guide us on how to promote healthy aging and prevent age-related diseases. |
format | Online Article Text |
id | pubmed-9905409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-99054092023-02-08 Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions Jin, Menglong Cai, Shi-Qing Neurosci Bull Review Aging is a major risk factor for many human diseases, including cognitive impairment, which affects a large population of the elderly. In the past few decades, our understanding of the molecular and cellular mechanisms underlying the changes associated with aging and age-related diseases has expanded greatly, shedding light on the potential role of these changes in cognitive impairment. In this article, we review recent advances in understanding of the mechanisms underlying brain aging under normal and pathological conditions, compare their similarities and differences, discuss the causative and adaptive mechanisms of brain aging, and finally attempt to find some rules to guide us on how to promote healthy aging and prevent age-related diseases. Springer Nature Singapore 2022-11-27 /pmc/articles/PMC9905409/ /pubmed/36437436 http://dx.doi.org/10.1007/s12264-022-00969-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Jin, Menglong Cai, Shi-Qing Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title | Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title_full | Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title_fullStr | Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title_full_unstemmed | Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title_short | Mechanisms Underlying Brain Aging Under Normal and Pathological Conditions |
title_sort | mechanisms underlying brain aging under normal and pathological conditions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905409/ https://www.ncbi.nlm.nih.gov/pubmed/36437436 http://dx.doi.org/10.1007/s12264-022-00969-9 |
work_keys_str_mv | AT jinmenglong mechanismsunderlyingbrainagingundernormalandpathologicalconditions AT caishiqing mechanismsunderlyingbrainagingundernormalandpathologicalconditions |