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Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature

Metastasis to the breast from extra-mammary malignancies are rare, accounting for less than 1% of all breast cancers. Endometrial cancer, a common gynecological malignancy, often spreads to the pelvis, abdominal lymph nodes, peritoneum or the lungs. Endometrial metastasis to the breast is extremely...

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Autores principales: Choo, Amadora Li En, Sim, Llewellyn Shao-jen, Sittampalam, Kesavan, Tan, Wei Chong, Tay, Amos Zhi En, Nadarajah, Ravichandran, Tan, Veronique Kiak Mien, Sim, Yirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905423/
https://www.ncbi.nlm.nih.gov/pubmed/36761429
http://dx.doi.org/10.3389/fonc.2022.1070744
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author Choo, Amadora Li En
Sim, Llewellyn Shao-jen
Sittampalam, Kesavan
Tan, Wei Chong
Tay, Amos Zhi En
Nadarajah, Ravichandran
Tan, Veronique Kiak Mien
Sim, Yirong
author_facet Choo, Amadora Li En
Sim, Llewellyn Shao-jen
Sittampalam, Kesavan
Tan, Wei Chong
Tay, Amos Zhi En
Nadarajah, Ravichandran
Tan, Veronique Kiak Mien
Sim, Yirong
author_sort Choo, Amadora Li En
collection PubMed
description Metastasis to the breast from extra-mammary malignancies are rare, accounting for less than 1% of all breast cancers. Endometrial cancer, a common gynecological malignancy, often spreads to the pelvis, abdominal lymph nodes, peritoneum or the lungs. Endometrial metastasis to the breast is extremely rare, and while there have been isolated case reports of endometrial serous carcinoma with breast metastasis, it has not been reported in the case of clear cell carcinoma. We present a rare case of a 70 year old Chinese lady who had a metastatic endometrial clear cell carcinoma with metastasis to the breast, mimicking an inflammatory breast cancer clinically. We reviewed the current literature and describe the challenges in differentiating primary from metastatic breast lesions, as well as clinical, radiological and histopathological features that may help to differentiate the two. Tumour metastasis to the breast via lymphatic or hematogenous route can affect their radiological features: the former mimicking inflammatory breast cancer and the latter with features similar to benign breast lesions. Regardless, histological features with immunohistochemical staining is still the gold standard in diagnosing metastatic breast lesions and determining their tissue of origin. Breast metastases from extra-mammary malignancies are uncommon and it is even rarer for endometrial clear cell carcinoma to spread to the breast. Nonetheless, this case highlights the importance of keeping an open mind and engaging a multidisciplinary team for the care of complex patients.
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spelling pubmed-99054232023-02-08 Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature Choo, Amadora Li En Sim, Llewellyn Shao-jen Sittampalam, Kesavan Tan, Wei Chong Tay, Amos Zhi En Nadarajah, Ravichandran Tan, Veronique Kiak Mien Sim, Yirong Front Oncol Oncology Metastasis to the breast from extra-mammary malignancies are rare, accounting for less than 1% of all breast cancers. Endometrial cancer, a common gynecological malignancy, often spreads to the pelvis, abdominal lymph nodes, peritoneum or the lungs. Endometrial metastasis to the breast is extremely rare, and while there have been isolated case reports of endometrial serous carcinoma with breast metastasis, it has not been reported in the case of clear cell carcinoma. We present a rare case of a 70 year old Chinese lady who had a metastatic endometrial clear cell carcinoma with metastasis to the breast, mimicking an inflammatory breast cancer clinically. We reviewed the current literature and describe the challenges in differentiating primary from metastatic breast lesions, as well as clinical, radiological and histopathological features that may help to differentiate the two. Tumour metastasis to the breast via lymphatic or hematogenous route can affect their radiological features: the former mimicking inflammatory breast cancer and the latter with features similar to benign breast lesions. Regardless, histological features with immunohistochemical staining is still the gold standard in diagnosing metastatic breast lesions and determining their tissue of origin. Breast metastases from extra-mammary malignancies are uncommon and it is even rarer for endometrial clear cell carcinoma to spread to the breast. Nonetheless, this case highlights the importance of keeping an open mind and engaging a multidisciplinary team for the care of complex patients. Frontiers Media S.A. 2023-01-25 /pmc/articles/PMC9905423/ /pubmed/36761429 http://dx.doi.org/10.3389/fonc.2022.1070744 Text en Copyright © 2023 Choo, Sim, Sittampalam, Tan, Tay, Nadarajah, Tan and Sim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Choo, Amadora Li En
Sim, Llewellyn Shao-jen
Sittampalam, Kesavan
Tan, Wei Chong
Tay, Amos Zhi En
Nadarajah, Ravichandran
Tan, Veronique Kiak Mien
Sim, Yirong
Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title_full Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title_fullStr Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title_full_unstemmed Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title_short Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature
title_sort breast metastasis from endometrial clear cell carcinoma: a case report and review of the literature
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905423/
https://www.ncbi.nlm.nih.gov/pubmed/36761429
http://dx.doi.org/10.3389/fonc.2022.1070744
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