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Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial

BACKGROUND: YS-1402, which is a polymerized form of the synthetic prostacyclin agonist ONO-1301, has been proven in several preclinical studies to induce therapeutic effects for patients with ischemic cardiomyopathy (ICM). In this human study, we assessed the safety, tolerability, and efficacy of YS...

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Detalles Bibliográficos
Autores principales:	Kawamura, Takuji, Yoshioka, Daisuke, Kawamura, Masashi, Matsuura, Ryohei, Kawamura, Ai, Misumi, Yusuke, Mikami, Tsubasa, Sawa, Yoshiki, Miyagawa, Shigeru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905424/ https://www.ncbi.nlm.nih.gov/pubmed/36760570 http://dx.doi.org/10.3389/fcvm.2023.1047666

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