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Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid

Anti-p200 pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, with occasional involvement of mucosal lesions....

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Autores principales: Gao, Yangmin, Qian, Hua, Hashimoto, Takashi, Li, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905711/
https://www.ncbi.nlm.nih.gov/pubmed/36761755
http://dx.doi.org/10.3389/fimmu.2023.1118846
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author Gao, Yangmin
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
author_facet Gao, Yangmin
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
author_sort Gao, Yangmin
collection PubMed
description Anti-p200 pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, with occasional involvement of mucosal lesions. The mechanism of mucosal lesions involved in anti-p200 pemphigoid is still unclear. In the present study, we aimed to analyze published data on cases and case series of anti-p200 pemphigoid with mucosal lesions and explored the potential contribution of anti-p200 autoantibodies to mucosal lesions. A total of 32 papers that comprised 52 anti-p200 pemphigoid patients with various mucosal lesions were included in this review. Oral lesions were involved in 75.0% patients, followed by genital lesions (26.9%) and ocular lesions (11.54%). Only one patient had psoriasis, 26.9% patients had multiple mucosal lesions, and 30.8% cases had comorbidity of other AIBDs, particularly anti-laminin (LM) 332-type mucous membrane pemphigoid (MMP). In comparison with anti-LM332-type MMP, anti-BP180-type MMP and epidermolysis bullosa acquisita, higher frequency of genital lesions was identified as a unique character of anti-p200 pemphigoid with mucosal lesions. These results indicated that anti-p200 autoantibodies might contribute to mucosal lesions in a pattern different from other MMP-related autoantibodies, although its pathogenetic mechanisms are still unclear.
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spelling pubmed-99057112023-02-08 Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid Gao, Yangmin Qian, Hua Hashimoto, Takashi Li, Xiaoguang Front Immunol Immunology Anti-p200 pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, with occasional involvement of mucosal lesions. The mechanism of mucosal lesions involved in anti-p200 pemphigoid is still unclear. In the present study, we aimed to analyze published data on cases and case series of anti-p200 pemphigoid with mucosal lesions and explored the potential contribution of anti-p200 autoantibodies to mucosal lesions. A total of 32 papers that comprised 52 anti-p200 pemphigoid patients with various mucosal lesions were included in this review. Oral lesions were involved in 75.0% patients, followed by genital lesions (26.9%) and ocular lesions (11.54%). Only one patient had psoriasis, 26.9% patients had multiple mucosal lesions, and 30.8% cases had comorbidity of other AIBDs, particularly anti-laminin (LM) 332-type mucous membrane pemphigoid (MMP). In comparison with anti-LM332-type MMP, anti-BP180-type MMP and epidermolysis bullosa acquisita, higher frequency of genital lesions was identified as a unique character of anti-p200 pemphigoid with mucosal lesions. These results indicated that anti-p200 autoantibodies might contribute to mucosal lesions in a pattern different from other MMP-related autoantibodies, although its pathogenetic mechanisms are still unclear. Frontiers Media S.A. 2023-01-25 /pmc/articles/PMC9905711/ /pubmed/36761755 http://dx.doi.org/10.3389/fimmu.2023.1118846 Text en Copyright © 2023 Gao, Qian, Hashimoto and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gao, Yangmin
Qian, Hua
Hashimoto, Takashi
Li, Xiaoguang
Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title_full Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title_fullStr Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title_full_unstemmed Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title_short Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
title_sort potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905711/
https://www.ncbi.nlm.nih.gov/pubmed/36761755
http://dx.doi.org/10.3389/fimmu.2023.1118846
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