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Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized

The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-y...

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Autores principales: Whitaker, Carolina de Oliveira, Chamon, Raiane Cardoso, de Oliveira, Tamara Lopes Rocha, Nouér, Simone Aranha, dos Santos, Kátia Regina Netto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905938/
https://www.ncbi.nlm.nih.gov/pubmed/36608934
http://dx.doi.org/10.1016/j.bjid.2022.102737
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author Whitaker, Carolina de Oliveira
Chamon, Raiane Cardoso
de Oliveira, Tamara Lopes Rocha
Nouér, Simone Aranha
dos Santos, Kátia Regina Netto
author_facet Whitaker, Carolina de Oliveira
Chamon, Raiane Cardoso
de Oliveira, Tamara Lopes Rocha
Nouér, Simone Aranha
dos Santos, Kátia Regina Netto
author_sort Whitaker, Carolina de Oliveira
collection PubMed
description The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-year-old boy, from a low-income area of Rio de Janeiro, previously colonized by the same strain. During hospital stay, seven pvl-positive MRSA USA300-LV isolates were recovered by nasal swab, blood and abscess secretion. The patient underwent intravenous vancomycin, daptomycin, and oral sulfamethoxazole/trimethoprim, and was discharged after 45 days after full recovery. This is the first documented case of a community-acquired MRSA infection caused by the USA300-LV variant in Brazil in a previously colonized adolescent with no history of recent travel outside of Rio de Janeiro. The need for improved surveillance programs to detect MRSA colonization in order to control the spread of hypervirulent lineages among community and hospital settings is highlighted.
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spelling pubmed-99059382023-02-08 Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized Whitaker, Carolina de Oliveira Chamon, Raiane Cardoso de Oliveira, Tamara Lopes Rocha Nouér, Simone Aranha dos Santos, Kátia Regina Netto Braz J Infect Dis Case Report The methicillin-resistant Staphylococcus aureus (MRSA) USA300-Latin American variant (USA300-LV) lineage is well documented in northern Latin American countries. It has replaced established clones in hospital environments. We herein report a systemic infection caused by a USA300-LV isolate in a 15-year-old boy, from a low-income area of Rio de Janeiro, previously colonized by the same strain. During hospital stay, seven pvl-positive MRSA USA300-LV isolates were recovered by nasal swab, blood and abscess secretion. The patient underwent intravenous vancomycin, daptomycin, and oral sulfamethoxazole/trimethoprim, and was discharged after 45 days after full recovery. This is the first documented case of a community-acquired MRSA infection caused by the USA300-LV variant in Brazil in a previously colonized adolescent with no history of recent travel outside of Rio de Janeiro. The need for improved surveillance programs to detect MRSA colonization in order to control the spread of hypervirulent lineages among community and hospital settings is highlighted. Elsevier 2023-01-03 /pmc/articles/PMC9905938/ /pubmed/36608934 http://dx.doi.org/10.1016/j.bjid.2022.102737 Text en © 2023 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Whitaker, Carolina de Oliveira
Chamon, Raiane Cardoso
de Oliveira, Tamara Lopes Rocha
Nouér, Simone Aranha
dos Santos, Kátia Regina Netto
Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title_full Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title_fullStr Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title_full_unstemmed Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title_short Systemic infection caused by the methicillin-resistant Staphylococcus aureus USA300-LV lineage in a Brazilian child previously colonized
title_sort systemic infection caused by the methicillin-resistant staphylococcus aureus usa300-lv lineage in a brazilian child previously colonized
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905938/
https://www.ncbi.nlm.nih.gov/pubmed/36608934
http://dx.doi.org/10.1016/j.bjid.2022.102737
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