Somatic inactivation of breast cancer predisposition genes in tumors associated with pathogenic germline variants

BACKGROUND: Breast cancers (BCs) that arise in individuals heterozygous for a germline pathogenic variant in a susceptibility gene, such as BRCA1 and BRCA2, PALB2, and RAD51C, have been shown to exhibit biallelic loss in the respective genes and be associated with triple-negative breast cancer (TNBC...

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Detalles Bibliográficos
Autores principales: Lim, Belle W X, Li, Na, Mahale, Sakshi, McInerny, Simone, Zethoven, Magnus, Rowley, Simone M, Huynh, Joanne, Wang, Theresa, Lee, Jue Er Amanda, Friedman, Mia, Devereux, Lisa, Scott, Rodney J, Sloan, Erica K, James, Paul A, Campbell, Ian G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905963/
https://www.ncbi.nlm.nih.gov/pubmed/36315097
http://dx.doi.org/10.1093/jnci/djac196

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