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Pathological features of early pregnancy disorders in women living at high altitude in KSA

OBJECTIVES: Pregnancy at high altitudes is relatively challenging because of hypobaric hypoxia, which is associated with a smaller uterine artery diameter and diminished blood flow. Here, we investigated the histopathological characteristics of early pregnancy disorders among pregnant women living i...

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Autores principales: Nafie, Khalid, Hasan, Abdulkarim, Alshakhrit, Wesam K., Ismail, Amal, Abbadi, Osama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906012/
https://www.ncbi.nlm.nih.gov/pubmed/36818185
http://dx.doi.org/10.1016/j.jtumed.2022.10.010
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author Nafie, Khalid
Hasan, Abdulkarim
Alshakhrit, Wesam K.
Ismail, Amal
Abbadi, Osama
author_facet Nafie, Khalid
Hasan, Abdulkarim
Alshakhrit, Wesam K.
Ismail, Amal
Abbadi, Osama
author_sort Nafie, Khalid
collection PubMed
description OBJECTIVES: Pregnancy at high altitudes is relatively challenging because of hypobaric hypoxia, which is associated with a smaller uterine artery diameter and diminished blood flow. Here, we investigated the histopathological characteristics of early pregnancy disorders among pregnant women living in a high-altitude region (approximately 2200 m above sea level). METHODS: This cross-sectional study used retrospective data collection from a single tertiary hospital in a high-altitude region in KSA. Age and histopathology were analyzed in 495 women diagnosed with early pregnancy disorders (mainly miscarriage) in 2018–2020. RESULTS: Approximately one-fifth of pregnancies in this high-altitude region were lost before 24 weeks’ gestation, whereas 1150/6044 experienced miscarriage; 495 samples from those participants were sent for histopathological analysis. A total of 269 (54.34%) patients were younger than 35 years. Missed miscarriages accounted for 49.3% of miscarriages, followed by inevitable miscarriages (34.2%), which had a relatively higher frequency among mothers older than 35 years. The correlation between age and inevitable miscarriage was significant; ectopic pregnancy was diagnosed in 6.8%, molar pregnancy was detected in 6.26%, and blighted ovum was observed in 3.4%. CONCLUSION: The miscarriage rate in this high-altitude region was 19% of all pregnancies. Approximately half of the affected women were in their 30s. Missed miscarriage cases were relatively high in this region. The percentage of molar pregnancy was higher than those reported in prior studies, thus suggesting a need for monitoring and genetic workup practices. Furthermore, studies involving a larger population at high altitudes will be crucial for further risk assessment in addition to national studies on women living at sea level.
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spelling pubmed-99060122023-02-16 Pathological features of early pregnancy disorders in women living at high altitude in KSA Nafie, Khalid Hasan, Abdulkarim Alshakhrit, Wesam K. Ismail, Amal Abbadi, Osama J Taibah Univ Med Sci Original Article OBJECTIVES: Pregnancy at high altitudes is relatively challenging because of hypobaric hypoxia, which is associated with a smaller uterine artery diameter and diminished blood flow. Here, we investigated the histopathological characteristics of early pregnancy disorders among pregnant women living in a high-altitude region (approximately 2200 m above sea level). METHODS: This cross-sectional study used retrospective data collection from a single tertiary hospital in a high-altitude region in KSA. Age and histopathology were analyzed in 495 women diagnosed with early pregnancy disorders (mainly miscarriage) in 2018–2020. RESULTS: Approximately one-fifth of pregnancies in this high-altitude region were lost before 24 weeks’ gestation, whereas 1150/6044 experienced miscarriage; 495 samples from those participants were sent for histopathological analysis. A total of 269 (54.34%) patients were younger than 35 years. Missed miscarriages accounted for 49.3% of miscarriages, followed by inevitable miscarriages (34.2%), which had a relatively higher frequency among mothers older than 35 years. The correlation between age and inevitable miscarriage was significant; ectopic pregnancy was diagnosed in 6.8%, molar pregnancy was detected in 6.26%, and blighted ovum was observed in 3.4%. CONCLUSION: The miscarriage rate in this high-altitude region was 19% of all pregnancies. Approximately half of the affected women were in their 30s. Missed miscarriage cases were relatively high in this region. The percentage of molar pregnancy was higher than those reported in prior studies, thus suggesting a need for monitoring and genetic workup practices. Furthermore, studies involving a larger population at high altitudes will be crucial for further risk assessment in addition to national studies on women living at sea level. Taibah University 2022-11-22 /pmc/articles/PMC9906012/ /pubmed/36818185 http://dx.doi.org/10.1016/j.jtumed.2022.10.010 Text en © 2022 [The Author/The Authors] https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Nafie, Khalid
Hasan, Abdulkarim
Alshakhrit, Wesam K.
Ismail, Amal
Abbadi, Osama
Pathological features of early pregnancy disorders in women living at high altitude in KSA
title Pathological features of early pregnancy disorders in women living at high altitude in KSA
title_full Pathological features of early pregnancy disorders in women living at high altitude in KSA
title_fullStr Pathological features of early pregnancy disorders in women living at high altitude in KSA
title_full_unstemmed Pathological features of early pregnancy disorders in women living at high altitude in KSA
title_short Pathological features of early pregnancy disorders in women living at high altitude in KSA
title_sort pathological features of early pregnancy disorders in women living at high altitude in ksa
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906012/
https://www.ncbi.nlm.nih.gov/pubmed/36818185
http://dx.doi.org/10.1016/j.jtumed.2022.10.010
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